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bioRxiv ; 2021 Nov 15.
Artículo en Inglés | MEDLINE | ID: mdl-34816263


We seek to completely revise current models of airborne transmission of respiratory viruses by providing never-before-seen atomic-level views of the SARS-CoV-2 virus within a respiratory aerosol. Our work dramatically extends the capabilities of multiscale computational microscopy to address the significant gaps that exist in current experimental methods, which are limited in their ability to interrogate aerosols at the atomic/molecular level and thus ob-scure our understanding of airborne transmission. We demonstrate how our integrated data-driven platform provides a new way of exploring the composition, structure, and dynamics of aerosols and aerosolized viruses, while driving simulation method development along several important axes. We present a series of initial scientific discoveries for the SARS-CoV-2 Delta variant, noting that the full scientific impact of this work has yet to be realized. ACM Reference Format: Abigail Dommer 1† , Lorenzo Casalino 1† , Fiona Kearns 1† , Mia Rosenfeld 1 , Nicholas Wauer 1 , Surl-Hee Ahn 1 , John Russo, 2 Sofia Oliveira 3 , Clare Morris 1 , AnthonyBogetti 4 , AndaTrifan 5,6 , Alexander Brace 5,7 , TerraSztain 1,8 , Austin Clyde 5,7 , Heng Ma 5 , Chakra Chennubhotla 4 , Hyungro Lee 9 , Matteo Turilli 9 , Syma Khalid 10 , Teresa Tamayo-Mendoza 11 , Matthew Welborn 11 , Anders Christensen 11 , Daniel G. A. Smith 11 , Zhuoran Qiao 12 , Sai Krishna Sirumalla 11 , Michael O'Connor 11 , Frederick Manby 11 , Anima Anandkumar 12,13 , David Hardy 6 , James Phillips 6 , Abraham Stern 13 , Josh Romero 13 , David Clark 13 , Mitchell Dorrell 14 , Tom Maiden 14 , Lei Huang 15 , John McCalpin 15 , Christo- pherWoods 3 , Alan Gray 13 , MattWilliams 3 , Bryan Barker 16 , HarindaRajapaksha 16 , Richard Pitts 16 , Tom Gibbs 13 , John Stone 6 , Daniel Zuckerman 2 *, Adrian Mulholland 3 *, Thomas MillerIII 11,12 *, ShantenuJha 9 *, Arvind Ramanathan 5 *, Lillian Chong 4 *, Rommie Amaro 1 *. 2021. #COVIDisAirborne: AI-Enabled Multiscale Computational Microscopy ofDeltaSARS-CoV-2 in a Respiratory Aerosol. In Supercomputing '21: International Conference for High Perfor-mance Computing, Networking, Storage, and Analysis . ACM, New York, NY, USA, 14 pages.

Otolaryngol Head Neck Surg ; 159(2): 403, 2018 08.
Artículo en Inglés | MEDLINE | ID: mdl-29558630


Stachler RJ, Francis DO, Schwartz SR, et al. Clinical practice guideline: hoarseness (dysphonia) (update). Otolaryngol Head Neck Surg. 2018;158:S1-S42. (Original DOI: 10.1177/0194599817751030) Stachler RJ, Francis DO, Schwartz SR, et al. Clinical practice guideline: hoarseness (dysphonia) (update) executive summary. Otolaryngol Head Neck Surg. 2018;158:409-426. (Original DOI: 10.1177/0194599817751031) Krouse HJ, Reavis CW, Stachler RJ, Francis DO, O'Connor S. Plain language summary: hoarseness (dysphonia). Otolaryngol Head Neck Surg. 2018;158:427-431. (Original DOI: 10.1177/0194599817751137) In the March 2018 clinical practice guideline and associated articles David O. Francis and Seth R. Schwartz's affiliations were listed incorrectly. Dr Francis should have been affiliated with University of Wisconsin, Madison, Wisconsin, USA. Dr Schwartz should have been affiliated with Virginia Mason Medical Center, Seattle, Washington, USA. Additionally, in the Plain Language Summary the location of Wayne State University was listed as Allen Park, Michigan; it should have been Detroit, Michigan. These have been updated in the online issues.

Aust N Z J Psychiatry ; 49(12): 1087-206, 2015 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26643054


OBJECTIVES: To provide guidance for the management of mood disorders, based on scientific evidence supplemented by expert clinical consensus and formulate recommendations to maximise clinical salience and utility. METHODS: Articles and information sourced from search engines including PubMed and EMBASE, MEDLINE, PsycINFO and Google Scholar were supplemented by literature known to the mood disorders committee (MDC) (e.g., books, book chapters and government reports) and from published depression and bipolar disorder guidelines. Information was reviewed and discussed by members of the MDC and findings were then formulated into consensus-based recommendations and clinical guidance. The guidelines were subjected to rigorous successive consultation and external review involving: expert and clinical advisors, the public, key stakeholders, professional bodies and specialist groups with interest in mood disorders. RESULTS: The Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders (Mood Disorders CPG) provide up-to-date guidance and advice regarding the management of mood disorders that is informed by evidence and clinical experience. The Mood Disorders CPG is intended for clinical use by psychiatrists, psychologists, physicians and others with an interest in mental health care. CONCLUSIONS: The Mood Disorder CPG is the first Clinical Practice Guideline to address both depressive and bipolar disorders. It provides up-to-date recommendations and guidance within an evidence-based framework, supplemented by expert clinical consensus. MOOD DISORDERS COMMITTEE: Professor Gin Malhi (Chair), Professor Darryl Bassett, Professor Philip Boyce, Professor Richard Bryant, Professor Paul Fitzgerald, Dr Kristina Fritz, Professor Malcolm Hopwood, Dr Bill Lyndon, Professor Roger Mulder, Professor Greg Murray, Professor Richard Porter and Associate Professor Ajeet Singh. INTERNATIONAL EXPERT ADVISORS: Professor Carlo Altamura, Dr Francesco Colom, Professor Mark George, Professor Guy Goodwin, Professor Roger McIntyre, Dr Roger Ng, Professor John O'Brien, Professor Harold Sackeim, Professor Jan Scott, Dr Nobuhiro Sugiyama, Professor Eduard Vieta, Professor Lakshmi Yatham. AUSTRALIAN AND NEW ZEALAND EXPERT ADVISORS: Professor Marie-Paule Austin, Professor Michael Berk, Dr Yulisha Byrow, Professor Helen Christensen, Dr Nick De Felice, A/Professor Seetal Dodd, A/Professor Megan Galbally, Dr Josh Geffen, Professor Philip Hazell, A/Professor David Horgan, A/Professor Felice Jacka, Professor Gordon Johnson, Professor Anthony Jorm, Dr Jon-Paul Khoo, Professor Jayashri Kulkarni, Dr Cameron Lacey, Dr Noeline Latt, Professor Florence Levy, A/Professor Andrew Lewis, Professor Colleen Loo, Dr Thomas Mayze, Dr Linton Meagher, Professor Philip Mitchell, Professor Daniel O'Connor, Dr Nick O'Connor, Dr Tim Outhred, Dr Mark Rowe, Dr Narelle Shadbolt, Dr Martien Snellen, Professor John Tiller, Dr Bill Watkins, Dr Raymond Wu.

Antidepresivos/uso terapéutico , Antimaníacos/uso terapéutico , Antipsicóticos/uso terapéutico , Trastorno Bipolar/terapia , Trastorno Depresivo Mayor/terapia , Terapia Electroconvulsiva/métodos , Psicoterapia/métodos , Australia , Trastorno Depresivo/terapia , Quimioterapia Combinada , Humanos , Trastornos del Humor/terapia , Nueva Zelanda , Uso Fuera de lo Indicado , Psiquiatría , Sociedades Médicas
J Learn Disabil ; 38(6): 539-44, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-16392696


Response to Intervention (RTI) models have attracted great attention as an alternative to traditional methods used for identifying students with learning disabilities. A major feature of this approach is the implementation of academic interventions in general education and measuring the student's response to those interventions. A common question that needs to be addressed is the number of stages or tiers of intervention necessary in the Response to Intervention model. This article reviews three studies of RTI that investigate the RTI tiers. Sharon Vaughn and Rollanda O'Connor report on studies using the Standard Protocol approach to RTI. David Tilly reports on using the Problem Solving Model as an RTI model. This article summarizes the results of these three investigations.

Educación Especial/métodos , Discapacidades para el Aprendizaje/epidemiología , Discapacidades para el Aprendizaje/terapia , Tamizaje Masivo/métodos , Niño , Humanos , Discapacidades para el Aprendizaje/diagnóstico , Resultado del Tratamiento
Alcohol Clin Exp Res ; 25(1): 136-44, 2001 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-11198709


This manuscript represents the proceedings of a symposium at the 2000 RSA Meeting in Denver, Colorado. The organizer/chair was Ting-Kai Li. The presentations were: (1) Introduction to the Symposium, by Ting-Kai Li; (2) ALDH2 polymorphism and alcohol metabolism, by Shih-Jiun Yin; (3) ALDH2 promoter polymorphism and alcohol metabolism, by David W. Crabb; (4) Use of BrAC clamping to estimate alcohol elimination rates: Application to studies of the influence of genetic and environmental determinants, by Sean O'Connor; and (5) Effect of food and food composition on alcohol elimination rates as determined by clamping, by Vijay A. Ramchandani.

Alcohol Deshidrogenasa/genética , Consumo de Bebidas Alcohólicas/genética , Alcoholismo/genética , Aldehído Deshidrogenasa/genética , Depresores del Sistema Nervioso Central/metabolismo , Ambiente , Etanol/metabolismo , Alcohol Deshidrogenasa/metabolismo , Consumo de Bebidas Alcohólicas/metabolismo , Alcoholismo/metabolismo , Aldehído Deshidrogenasa/metabolismo , Aldehído Deshidrogenasa Mitocondrial , Depresores del Sistema Nervioso Central/farmacología , Dieta , Etanol/farmacología , Alimentos , Genotipo , Hemodinámica/efectos de los fármacos , Hemodinámica/genética , Humanos , Polimorfismo Genético
Porto Alegre; s.n; 2001. 186 p.
Tesis en Portugués | Index Psicología - Tesis | ID: pte-29604


Este trabalho estuda o filme Titanic (1997) para compreender o choque entre o amor hiper-real do drama romântico com o amor real de fora das telas do cinema em tempos pós-modernos. Para isso, une a psicologia social e a teoria do cinema através dos Estudos Culturais que propõem que o filme não seja o alvo final da pesquisa, mas que se o utilize para entender algo mais. Na análise textual do longa de James Cameron, é utilizada a abordagem estruturalista da narrativa, proposta por Graeme Turner, e as estratégias narrativas do drama romântico, apontados por Heitor Capuzzo. O contexto será examinado através do conceito de hiper-real, simulacro e sedução, de Jean Baudrillard, das características dos filmes pós-modernos, descritas por David Harvey e Steven Connor, e dos estudos sobre o amor romântico, realizados por Jurandir Costa, Anthony Giddens e Nathaniel Branden (AU)