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1.
Sci Rep ; 11(1): 24491, 2021 12 29.
Artículo en Inglés | MEDLINE | ID: mdl-34966184

RESUMEN

There is an ongoing need for scientific analysis to help governments and public health authorities make decisions regarding the COVID-19 pandemic. This article presents a methodology based on data mining that can offer support for coping with epidemic diseases. The methodological approach was applied in São Paulo, Rio de Janeiro and Manaus, the cities in Brazil with the most COVID-19 deaths until the first half of 2021. We aimed to predict the evolution of COVID-19 in metropolises and identify air quality and meteorological variables correlated with confirmed cases and deaths. The statistical analyses indicated the most important explanatory environmental variables, while the cluster analyses showed the potential best input variables for the forecasting models. The forecast models were built by two different algorithms and their results have been compared. The relationship between epidemiological and environmental variables was particular to each of the three cities studied. Low solar radiation periods predicted in Manaus can guide managers to likely increase deaths due to COVID-19. In São Paulo, an increase in the mortality rate can be indicated by drought periods. The developed models can predict new cases and deaths by COVID-19 in studied cities. Furthermore, the methodological approach can be applied in other cities and for other epidemic diseases.


Asunto(s)
COVID-19/epidemiología , COVID-19/mortalidad , Minería de Datos/métodos , Brasil/epidemiología , COVID-19/patología , Ciudades/epidemiología , Humanos , Modelos Teóricos , Morbilidad , Pandemias/prevención & control , SARS-CoV-2/patogenicidad
2.
Artículo en Inglés | MEDLINE | ID: mdl-34770128

RESUMEN

Continuous coal mining results in dramatic regional land use change, and significantly influences the sustainable development of coal resource-based cities. Present studies pay little attention to the characteristics and regularities of land use change in coal resource-based cities, caused by underground coal mining in high groundwater areas. Based on the Landsat remote sensing images of 1999, 2000, 2010, and 2018 of Huaibei City, a typical coal resource-based city of a high ground water area on the North China Plain, this paper applies the dynamic degree and transition matrix of land use to analyze the land use change characteristics, and identify the regularity between land use type and coal mining production in this coal resource-based city. Results show that the land use change in the research area presents an overall characteristic of a constant increase in water area, urban construction land, and rural settlement land, and a continuous decrease in cultivated land. Cultivated land is converted into a water area, urban construction land, and rural settlement land, and rural settlement land and cultivated land are converted bidirectionally. The land use change in this coal resource-based city demonstrates significant reliance on coal resources, and coal mining is significantly related to the area of cultivated land, water area, and rural settlement land, which demonstrates that continuous large-scale coal mining results in damage to cultivated land, a decrease in rural settlement land, and an increase in water area. The research result contributes to the sustainable land use of coal resource-based cities.


Asunto(s)
Minas de Carbón , Agua Subterránea , China , Ciudades , Carbón Mineral , Minería
3.
J Healthc Eng ; 2021: 3400943, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34603646

RESUMEN

The paper presents a recommendation model for developing new smart city and smart health projects. The objective is to provide recommendations to citizens about smart city and smart health startups to improve entrepreneurship and leadership. These recommendations may lead to the country's advancement and the improvement of national income and reduce unemployment. This work focuses on designing and implementing an approach for processing and analyzing tweets inclosing data related to smart city and smart health startups and providing recommended projects as well as their required skills and competencies. This approach is based on tweets mining through a machine learning method, the Word2Vec algorithm, combined with a recommendation technique conducted via an ontology-based method. This approach allows discovering the relevant startup projects in the context of smart cities and makes links to the needed skills and competencies of users. A system was implemented to validate this approach. The attained performance metrics related to precision, recall, and F-measure are, respectively, 95%, 66%, and 79%, showing that the results are very encouraging.


Asunto(s)
Medios de Comunicación Sociales , Algoritmos , Ciudades , Minería de Datos , Humanos , Aprendizaje Automático
4.
Toxicology ; 458: 152848, 2021 06 30.
Artículo en Inglés | MEDLINE | ID: mdl-34217791

RESUMEN

High maternal serum bile acid level is common and sometimes harmful to the gravida. This study aimed to confirm the bile acid phenotypic change caused by prenatal ethanol exposure (PEE) and elucidate its placental mechanism. Pregnant Wistar rats were administered intragastrically with ethanol 4 g/kg⋅d from gestational day 9-20. Total bile acids (TBA) were detected in maternal, fetal serum and placental tissues, increasing significantly in the serum but no significant change in the placental tissues. Meta-analysis was performed and verified the efficacy of the PEE-induced model based on published data from several relevant studies. Mining of microarray data from human and rat placental sources identified the involvement of bile acid metabolism and its significant genes, which were verified by RT-qPCR and western blotting on tissues and treated BeWo cells with the administration of FXR/PXR siRNAs or FXR/PXR agonists. Our examination, consistent with microarray data and wet experiments, showed that organic anion transporter polypeptide-related protein 2B1 (Oatp2b1), multidrug resistance-associated proteins 3 (Mrp3) and breast cancer resistance protein (Bcrp) expression were increased, while nuclear receptor farnesoid X receptor (Fxr) was decreased but pregnane X receptor (Pxr) was increased. Furthermore, the interventional experiments confirmed that FXR regulated Bcrp while PXR regulated Oatp2b1 and Mrp3. In summary, PEE could induce high bile acid level in maternal serum and its mechanism is associated with the high expression of BCRP/MRP3/OATP2B1 in the placenta through up-regulating PXR and down-regulating FXR, thereby leading to an excessive bile acid transport to maternal blood via the placenta. Our study provides a novel perspective in terms of placenta, explaining the increased maternal blood bile acids under the toxicity of PEE.


Asunto(s)
Ácidos y Sales Biliares/metabolismo , Depresores del Sistema Nervioso Central/toxicidad , Etanol/toxicidad , Redes y Vías Metabólicas/efectos de los fármacos , Placenta/metabolismo , Animales , Ácidos y Sales Biliares/sangre , Proteínas Portadoras/metabolismo , Línea Celular , Minería de Datos , Femenino , Regulación de la Expresión Génica , Humanos , Masculino , Análisis por Micromatrices , Embarazo , ARN Interferente Pequeño/farmacología , Ratas , Ratas Wistar , Receptores Citoplasmáticos y Nucleares
5.
Cad Saude Publica ; 37(5): e00100119, 2021.
Artículo en Portugués | MEDLINE | ID: mdl-34008697

RESUMEN

Leptospirosis is related to problems with environmental sanitation, and the incidence tends to increase during flood periods. Considering issues related to climate change, floods can be expected to increase. Floods do not affect populations homogeneously, and communities with worse socioeconomic conditions tend to be impacted more heavily. In order to determine whether the number of floods increases the incidence of leptospirosis and its relationship to contextual variables, the study used socioeconomic, environmental, and disease occurrence data at the municipal (county) level. Municipalities suffering problems with sewage disposal showed a higher risk of leptospirosis incidence. Total flooding since the municipality's declaration of flood emergency was an important risk marker for leptospirosis incidence. Regression tree modeling proved useful for estimating leptospirosis incidence in Brazil.


Asunto(s)
Inundaciones , Leptospirosis , Brasil/epidemiología , Ciudades/epidemiología , Minería de Datos , Humanos , Leptospirosis/epidemiología
6.
J Hist Med Allied Sci ; 76(2): 123-146, 2021 Apr 08.
Artículo en Inglés | MEDLINE | ID: mdl-33616180

RESUMEN

Public health historians have repeatedly shown that the theory, policy, and practice of group prophylactics far predate their alleged birth in industrial modernity, and regularly draw on Galenic principles. While the revision overall has been successful, its main focus on European cities entails a major risk, since city dwellers were a minority even in Europe's most urbanised regions. At the same time, cities continue to be perceived and presented as typically European, which stymies transregional and comparative studies based at least in part on non- or extra-urban groups. Thus, any plan to both offer an accurate picture of public health's deeper past and fundamentally challenge a narrative of civilizational progress wedded to Euro-American modernity ("stagism") would benefit from looking beyond cities and their unique health challenges. The present article begins to do so by focusing on two ubiquitous groups, often operating outside cities and facing specific risks: miners and shipmates. Evidence for these communities' preventative interventions and the extent to which they drew on humoral theory is rich yet uneven for Europe between the thirteenth and sixteenth centuries. Methodological questions raised by this unevenness can be addressed by connecting different scales of evidence, as this article demonstrates. Furthermore, neither mining nor maritime trade was typically European, thus building a broader base for transregional studies and comparisons.


Asunto(s)
Minería/historia , Salud Pública/historia , Navíos/historia , Transportes/historia , Ciudades , Europa (Continente) , Historia del Siglo XV , Historia del Siglo XVI , Historia Medieval , Humanos
7.
Environ Sci Pollut Res Int ; 28(11): 13562-13569, 2021 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-33185795

RESUMEN

Selenium (Se) presents a dual role to human body, harmful or beneficial, depending on its concentration. The exposure to this element has been associated to coal mining. Health risk assessment allows estimating and evaluating the risks that environmental hazards pose to vulnerable groups of populations. The present study aimed to analyze the risk of exposure to Se through multiple exposure pathways in children living in Candiota city, where the largest coal reserve of Brazil is located. Data from previous environmental (air, soil, drinking water, and food) and population parameters (age, weight, and food intake) were used to assess the health risk, which was calculated with real values (extracted from the population) and fixed reference values, based on the USEPA recommendation. Most of the children had low health risk (HQ < 1); however, in the most conservative scenarios (higher Se values in the different matrices), there was a high health risk in both scenarios, using population data or the USEPA parameters. The mean HQ using reference values was twice higher than using real values. Se content in air, soil, and drinking water did not represent important average daily dose in both scenarios. While, food intake was a main source of Se exposure, contributing with 96.9% of total Se intake. The findings of this study reinforce the importance of food intake for exposure to Se and the difference between HQs using population measures and fixed parameters of the USEPA highlights the need for adaptations to local scenarios for a better dimensioning of toxicological risk management actions.


Asunto(s)
Minas de Carbón , Selenio , Brasil , Niño , Ciudades , Exposición a Riesgos Ambientales , Humanos , Minería , Medición de Riesgo , Selenio/análisis
8.
J Urban Health ; 98(2): 285-295, 2021 04.
Artículo en Inglés | MEDLINE | ID: mdl-33230671

RESUMEN

To overcome the challenge of obtaining accurate data on community food retail, we developed an innovative tool to automatically capture food retail data from Google Earth (GE). The proposed method is relevant to non-commercial use or scholarly purposes. We aimed to test the validity of web sources data for the assessment of community food retail environment by comparison to ground-truth observations (gold standard). A secondary aim was to test whether validity differs by type of food outlet and socioeconomic status (SES). The study area included a sample of 300 census tracts stratified by SES in two of the largest cities in Brazil, Rio de Janeiro and Belo Horizonte. The GE web service was used to develop a tool for automatic acquisition of food retail data through the generation of a regular grid of points. To test its validity, this data was compared with the ground-truth data. Compared to the 856 outlets identified in 285 census tracts by the ground-truth method, the GE interface identified 731 outlets. In both cities, the GE interface scored moderate to excellent compared to the ground-truth data across all of the validity measures: sensitivity, specificity, positive predictive value, negative predictive value and accuracy (ranging from 66.3 to 100%). The validity did not differ by SES strata. Supermarkets, convenience stores and restaurants yielded better results than other store types. To our knowledge, this research is the first to investigate using GE as a tool to capture community food retail data. Our results suggest that the GE interface could be used to measure the community food environment. Validity was satisfactory for different SES areas and types of outlets.


Asunto(s)
Abastecimiento de Alimentos , Restaurantes , Brasil , Ciudades , Comercio , Minería de Datos , Humanos , Características de la Residencia
9.
Ecotoxicol Environ Saf ; 207: 111234, 2021 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-32916529

RESUMEN

The activity and fate of heavy metals (HMs) from mining and smelting activities in farmland soil is of great significance to effectively prevent the excessive enrichment of HMs in crops. This study focuses on Baiyin area, a typical mining city in northwest China. In this example, the sources, speciation, and fate of HMs in the farmland soil, and the migration and enrichment characteristics of HMs in the different parts of crops planted in different areas were studied in detail combining the chemical sequential extraction and Pb isotope approaches. Results showed that the mean anthropogenic contributions of HMs in farmland soils were approximately 85%, 88%, 76%, and 41% for the ore district (OD), Xidagou sewage irrigation area (XSIA), Dongdagou sewage irrigation area, and the Yellow River irrigation area, respectively, and the risk that HMs were excessively accumulated in crops in OD and XSIA was high. Compared with soil residual fractions, the isotope ratios 206Pb/207Pb in non-residual fractions (1.1304-1.1669) were closer to the values of local ores, suggesting that anthropogenic HMs from mining and smelting activities were mainly enriched in the non-residual fractions. The isotope ratios 206Pb/207Pb in crops (1.1398-1.1686) further confirmed that those anthropogenic HMs were more easily absorbed and concentrated by crops. HMs contents in leaves from OD and XSIA were generally higher than that in roots, suggesting that atmospheric deposition in OD and XSIA had a greater impact on the HMs concentration of crop leaves,while the excess rate of HMs in grain/fruit was the lowest in all parts of crops. The division and classification of crop planting in mining area can effectively help minimize the risk that HMs from anthropogenic source enter the human body through the food chain.


Asunto(s)
Agricultura/métodos , Metales Pesados/análisis , Minería , Contaminantes del Suelo/análisis , China , Ciudades , Productos Agrícolas/química , Grano Comestible/química , Monitoreo del Ambiente/métodos , Granjas , Humanos , Raíces de Plantas/química , Ríos , Aguas del Alcantarillado , Suelo/química
10.
Sci Total Environ ; 753: 141821, 2021 Jan 20.
Artículo en Inglés | MEDLINE | ID: mdl-32891993

RESUMEN

Intense human disturbance has made algal bloom a prominent environmental problem in gate-controlled urban water bodies. Urban water bodies present the characteristics of natural rivers and lakes simultaneously, whose algal blooms may manifest multi-factor interactions. Hence, effective regulation strategies require a multi-factor analysis to understand local blooming mechanisms. This study designed a holistic multi-factor analysis framework by integrating five data mining techniques. First, the Kolmogorov-Smirnov test was conducted to screen out the possible explanatory variables. Then, correlation analyses and principal component analyses were performed to identify variable collinearity and mutual causality, respectively. After collinearity and mutual causality were treated prudently by using orthogonalization and instrumental variables, multilinear regression can be properly conducted to quantify factor contributions to algae growth. Lastly, a decision tree was used innovatively to depict the limiting threshold curves of each driving factor that restricts algae growth under different circumstances. The driving factors, their contributions, and the limiting threshold curves compose the complete blooming mechanisms, thus providing a clear direction for the targeted regulation task. A typical case study was performed in Suzhou, a Chinese city with an intricate gate-controlled river network. Results confirmed that climatic factors (i.e., water temperature and solar radiation), hydrodynamic factors (i.e., flow velocity), nutrients (i.e., phosphorus and nitrogen), and external loadings contributed 49.3%, 21.7%, 21.3%, and 7.7%, respectively, to algae growth. These results indicate that a joint regulation strategy is urgently required. Future studies can focus on coupling the revealed mechanisms with an ecological model to provide a comprehensive toolkit for the optimization of an adaptive joint regulation plan under the background of global warming.


Asunto(s)
Monitoreo del Ambiente , Eutrofización , China , Ciudades , Minería de Datos , Análisis Factorial , Humanos , Lagos , Fósforo/análisis
11.
Sci Total Environ ; 752: 141938, 2021 Jan 15.
Artículo en Inglés | MEDLINE | ID: mdl-32898804

RESUMEN

Secondary salinization of freshwater ecosystems is of increasing global concern. One of the main causes are the effluents of the potash mining industry containing high concentrations of major ions (Cl-, Na+, Mg2+, K+). In Germany, the ongoing discharge of effluents into the River Werra led to a strong impoverishment of the biodiversity and abundance of local species. Young cohorts of many freshwater fish are completely absent suggesting reproductive failure under these conditions. Therefore, the aim of the study was to experimentally investigate the effects of high concentrations and imbalances of ions that are prevalent in potash mining effluents on reproductive traits of native freshwater teleosts. Sperm motility parameters of the common roach, Rutilus rutilus, and European perch, Perca fluviatilis, were assessed as well as fertilization rate, egg size, hatching, malformations and mortality of embryonic and larval stages of roach. Concentrations of the permitted thresholds (HT) and future thresholds (LT) as well as three ion solutions containing high Mg2+ (Mg), high K+ (K) and both in combination (Mg + K) were tested. Curvilinear velocity and linearity of perch spermatozoa were elevated with potentially adverse effects on fertilization success. Sperm motility parameters and fertilization rate of roach were not affected. However, egg sizes of roach were increased in all groups due to the osmotic action of ions and in LT, premature hatch was observed. Furthermore, all groups comprised a higher number of malformations including pericardial edema and spine curvatures and group HT exhibited a higher mortality rate compared to control. The results clearly demonstrated that particularly the sum of high concentrations of ions, as prevalent in HT and LT, rather than individual ion species exerts detrimental effects on early development of roach potentially increasing overall mortality under natural conditions. These results emphasize that currently permitted and future thresholds are exceeding tolerated ion concentrations.


Asunto(s)
Cyprinidae , Percas , Animales , Mezclas Complejas , Ecosistema , Alemania , Humanos , Iones , Masculino , Minería , Motilidad Espermática
14.
Cad. Saúde Pública (Online) ; 37(5): e00100119, 2021. tab, graf
Artículo en Portugués | LILACS | ID: biblio-1249439

RESUMEN

A leptospirose se relaciona a problemas de saneamento ambiental, com incremento de casos em períodos de inundações. Levando-se em consideração as questões relacionadas a mudanças climáticas, as inundações tendem a um aumento. As inundações não atingem as populações de maneira homogênea, em geral os menos favorecidos em termos socioeconômicos são os mais acometidos. Para saber se o número de inundações aumentaria a incidência de leptospirose e sua relação com as variáveis contextuais, utilizou-se dados socioeconômicos, ambientais e de ocorrência da doença no nível municipal. Os municípios que tinham problemas no esgotamento sanitário apresentaram maior risco para a ocorrência da leptospirose. O total de inundações adquirida a partir da decretação pela autoridade municipal constituiu um importante marcador de risco para a ocorrência de leptospirose. A modelagem de árvore de regressão mostrou-se útil para estimar a ocorrência de leptospirose no Brasil.


Leptospirosis is related to problems with environmental sanitation, and the incidence tends to increase during flood periods. Considering issues related to climate change, floods can be expected to increase. Floods do not affect populations homogeneously, and communities with worse socioeconomic conditions tend to be impacted more heavily. In order to determine whether the number of floods increases the incidence of leptospirosis and its relationship to contextual variables, the study used socioeconomic, environmental, and disease occurrence data at the municipal (county) level. Municipalities suffering problems with sewage disposal showed a higher risk of leptospirosis incidence. Total flooding since the municipality's declaration of flood emergency was an important risk marker for leptospirosis incidence. Regression tree modeling proved useful for estimating leptospirosis incidence in Brazil.


La leptospirosis se relaciona con problemas de saneamiento ambiental, así como con el incremento de casos en períodos de inundaciones. Teniendo en consideración las cuestiones relacionadas con el cambio climático, las inundaciones tienden a aumentar. Las inundaciones no afectan a las poblaciones de manera homogénea, en general, los menos favorecidos en términos socioeconómicos son los más afectados. Para saber si el número de inundaciones aumentaría la incidencia de leptospirosis, y su relación con variables contextuales, se utilizaron datos socioeconómicos, ambientales y de ocurrencia de la enfermedad en el nivel municipal. Los municipios que poseían problemas en el alcantarillado sanitario presentaron un mayor riesgo para la ocurrencia de leptospirosis. El total de inundaciones sufridas a partir de su reconocimiento oficial por parte de la autoridad municipal constituyó un importante marcador de riesgo para la ocurrencia de leptospirosis. El modelo de árbol de regresión se mostró útil para estimar la ocurrencia de leptospirosis en Brasil.


Asunto(s)
Humanos , Inundaciones , Leptospirosis/epidemiología , Brasil/epidemiología , Ciudades/epidemiología , Minería de Datos
15.
J Environ Public Health ; 2020: 6668488, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33293966

RESUMEN

Exposure to high concentrations of radon gas is the leading cause of lung cancer for nonsmokers according to the World Health Organization (WHO) figures. With poor ventilation standards and lack of awareness among Jordanians, constant monitoring of radon concentrations is vital. Multiple efforts have been made since the 1990s in order to create a national radon map of Jordan, by acquiring average values of radon concentrations in major Jordanian cities. This study aims to replicate those efforts using a more accurate and modern way of detection for the purpose of comparing the current values with literature values and to update the previous radon concentration map of Jordan. The study concludes that radon concentrations in Jordan have mostly increased in the past 30 years from an overall average of 52 Bq/m3 to an average of 60.4 Bq/m3. Despite the increase, these results are considered under the threat line that is estimated conventionally by most of the international environmental and radiation-related organizations, which is 100-300 Bq/m3. It should be noted that only the Russeifa city has scored a value higher than the estimated threat line. This is due to the existence of abundant phosphate mines filled with condensed radon levels leaking from these ores. It is expected that radon concentrations in Jordan will increase in the coming years with the continuous urban sprawl and lack of public awareness about the radon gas health issue. A number of suggestions have been proposed in this study that could help the Jordanian society avoid a future possible health threat.


Asunto(s)
Contaminantes Radiactivos del Aire/análisis , Contaminación del Aire Interior/análisis , Exposición a la Radiación/análisis , Radón/análisis , Ciudades , Vivienda , Humanos , Jordania , Minería , Exposición a la Radiación/normas
16.
Entramado ; 16(2): 112-124, jul.-dic. 2020.
Artículo en Español | LILACS-Express | LILACS | ID: biblio-1149271

RESUMEN

RESUMEN El propósito de este artículo es exponer la preocupación suscitada tanto por la ciudadanía de Bucaramanga, ciudad capital del departamento de Santander ubicada al nororiente de Colombia como un territorio que se debate entre la necesidad de preservar el agua que llega del páramo de Santurbán y la importancia de conservar la tradición minera en sus municipios cercanos. Para alcanzar este objetivo se recurrió a la realización de entrevistas semiestructuradas a algunos pobladores de la zona rural del páramo de Santurbán y se constató una revisión de las publicaciones periódicas que circularon en los años 2010 y 2011. Esta información se entrecruzó con algunos textos teóricos para comprender el impacto de la problemática ambiental. Una de las conclusiones de este artículo es la evidente necesidad de conservar el páramo de Santurbán como sustento hídrico de Bucaramanga y su área metropolitana; lo cual ha llevado a la movilización de gran parte de la ciudadanía, a pesar de las necesidades de otras poblaciones que derivan su sustento de la minería a pequeña escala.


ABSTRACT The purpose of this article is to expose the concern raised by both the citizens of Bucaramanga, the capital city of the department of Santander located in northeastern Colombia and a territory that is torn between the need to preserve the water that arrives from the Santurbán wasteland and the importance of preserving the mining tradition in its nearby municipalities. To achieve this objective, semi-structured interviews were carried out with some residents of the rural area of the Santurbán páramo and a review of the periodical publications that circulated in 2010 and 2011 was found. This information was intertwined with some theoretical texts for understand the impact of environmental issues. One of the conclusions of this article is the obvious need to conserve the Santurbán páramo as a water support for Bucaramanga and its metropolitan area; which has led to the mobilization of much of the citizenship, despite the needs of other populations that derive their livelihood from small-scale mining.


RESUMO O objetivo deste artigo é expor a preocupação levantada pelos cidadãos de Bucaramanga, capital do departamento de Santander localizada no nordeste da Colômbia, e um território dividido entre a necessidade de preservar a água que chega do deserto de Santurbán e a importância de preservar a tradição mineradora em seus municípios vizinhos. Para atingir esse objetivo, foram realizadas entrevistas semiestruturadas com alguns moradores da área rural de Santurbán páramo e foi encontrada uma revisão das publicações periódicas que circularam em 2010 e 2011. Essas informações foram entrelaçadas com alguns textos teóricos para entenda o impacto das questões ambientais. Uma das conclusões deste artigo é a necessidade óbvia de conservar o Santurbán páramo como suporte hídrico para Bucaramanga e sua área metropolitana; o que levou à mobilização de grande parte da cidadania, apesar das necessidades de outras populações que derivam seu sustento da mineração em pequena escala.

17.
Cell Rep ; 33(3): 108296, 2020 10 20.
Artículo en Inglés | MEDLINE | ID: mdl-33086069

RESUMEN

CellMiner-SCLC (https://discover.nci.nih.gov/SclcCellMinerCDB/) integrates drug sensitivity and genomic data, including high-resolution methylome and transcriptome from 118 patient-derived small cell lung cancer (SCLC) cell lines, providing a resource for research into this "recalcitrant cancer." We demonstrate the reproducibility and stability of data from multiple sources and validate the SCLC consensus nomenclature on the basis of expression of master transcription factors NEUROD1, ASCL1, POU2F3, and YAP1. Our analyses reveal transcription networks linking SCLC subtypes with MYC and its paralogs and the NOTCH and HIPPO pathways. SCLC subsets express specific surface markers, providing potential opportunities for antibody-based targeted therapies. YAP1-driven SCLCs are notable for differential expression of the NOTCH pathway, epithelial-mesenchymal transition (EMT), and antigen-presenting machinery (APM) genes and sensitivity to mTOR and AKT inhibitors. These analyses provide insights into SCLC biology and a framework for future investigations into subtype-specific SCLC vulnerabilities.


Asunto(s)
Minería de Datos/métodos , Carcinoma Pulmonar de Células Pequeñas/genética , Carcinoma Pulmonar de Células Pequeñas/metabolismo , Algoritmos , Línea Celular Tumoral , Metilación de ADN/genética , Epigénesis Genética/genética , Epigenómica/métodos , Transición Epitelial-Mesenquimal/genética , Regulación Neoplásica de la Expresión Génica/genética , Genómica/métodos , Humanos , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/metabolismo , Fenómenos Farmacológicos y Toxicológicos , Reproducibilidad de los Resultados , Programas Informáticos , Factores de Transcripción/genética
18.
Radiat Prot Dosimetry ; 191(3): 296-309, 2020 Dec 03.
Artículo en Inglés | MEDLINE | ID: mdl-33103199

RESUMEN

Studies have been carried in 126 dwellings for indoor radon levels and 43 soil samples for radium and radon exhalation rate of Abirem communities in Eastern region of Ghana. The measurements were done using CR-39 and HPGe techniques. Indoor radon and mean concentration ranged from 23.8 to 125.7 Bq/m3, 54.7 ± 23.7 Bq/m3. Bedroom, kitchen, and sitting varied from 30.8 to 125.7 Bq/m3, 23.8-63.9 Bq/m3 and 23.8 to 58.4 Bq/m3. Strong and weak Pearson correlation were found between radium and radon in soil, radium and indoor radon concentration. Radium concentration and mean were found to be varied from 19.5 to 38.9 Bq/kg, 29.0 ± 16.0 Bq/kg. The radon exhalation rate and mean in soil were also found to be varied from 21.3 to 112.1 µBq/m2h, 65.1 ± 27.6 µBq/m2h. Indoor radon values and radium concentration in dwellings and soil recorded 8% and 38%, respectively, more than action proposed by WHO and UNSCEAR 2000. The estimated annual effective doses and cancer risk were less than the average values recommended by UNSCEAR and ICRP.


Asunto(s)
Contaminación del Aire Interior , Monitoreo de Radiación , Radio (Elemento) , Radón , Contaminación del Aire Interior/análisis , Ciudades , Ghana , Vivienda , Minería , Radio (Elemento)/análisis , Radón/análisis , Suelo
19.
Chemosphere ; 254: 126904, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-32957297

RESUMEN

Estimating bioaccessible content of mercury in soils is essential in evaluating risks that contaminated soils pose. In this study, soil samples spiked with HgCl2 through adsorption were used to test the effects of liming, soil organic matter, soil depth, and Hg concentration on the following bioaccessibility tests: dilute nitric acid at room temperature, dilute nitric acid at body temperature, Simplified Bioaccessibility Extraction Test (SBET) method, and gastric phase of the In vitro Gastrointestinal (IVG) protocol. Soil and sediment samples from Descoberto, Minas Gerais (Brazil), a city with a well-known record of Hg contamination from artisanal mining, were subjected to these bioaccessibility tests for the first time, and the different methods of estimating bioaccessible content were compared. Bioaccessible fractions in spiked samples ranged from 10% to 60%, and this high bioaccessibility was due to the highly soluble species of Hg and the short time under adsorption. In general, clay and organic matter decreased bioaccessible content. Although the soil in Descoberto is undoubtedly polluted, mercury bioaccessibility in that area is low. In general, dilute nitric acid estimated higher bioaccessible content in soil samples, whereas the SBET method estimated higher bioaccessible content in sediment samples. In multivariate analysis, two groups of bioaccessibility tests arise: one with the two nitric acid tests, and the other with SBET and the gastric phase of the IVG protocol. The addition of pepsin and glycine in the last two tests suggests a more reliable test for assessing mercury bioaccessibility.


Asunto(s)
Arcilla/química , Sustancias Húmicas/análisis , Mercurio/análisis , Minería , Contaminantes del Suelo/análisis , Suelo/química , Adsorción , Disponibilidad Biológica , Brasil , Ciudades , Mucosa Gástrica/metabolismo , Humanos , Mucosa Intestinal/metabolismo , Mercurio/metabolismo , Modelos Biológicos , Ácido Nítrico/química , Contaminantes del Suelo/metabolismo
20.
Artículo en Inglés | MEDLINE | ID: mdl-32916867

RESUMEN

This study assessed the significance and potential impact of potentially toxic element (PTE) (i.e., Mn, Pb, Cu, Zn, Cr, Cd, and Ni) pollution in the surface soil from an abandoned manganese mining area in Xiangtan City, Hunan Province, China, on the health of residents. The risks were sequentially evaluated using a series of protocols including: the geo-accumulation index (Igeo), pollution load index (PLI), potential ecological risk index (RI), and implications for human health from external exposures using the hazard quotient (HQ), hazard index (HI) and carcinogenic risk (CR). The results revealed that Mn and Cd were the major pollutants in the soil samples. The ecological risk assessment identified moderate risks, which were mainly derived from Cd (82.91%). The results of the health risk assessment revealed that generally across the area, the non-carcinogenic risk was insignificant, and the carcinogenic risk was at an acceptable level. However, due to local spatial fluctuation, some of the sites presented a non-carcinogenic risk to children. The soil ingestion pathway is the main route of exposure through both non-carcinogenic and carcinogenic risks, with Mn being the major contributor to non-carcinogenic risk, with Cr and Cd the major contributors to carcinogenic risk. In addition, three pollution sources were identified through the Pearson correlation coefficient and principal component analysis (PCA), which included: a. mining activities and emissions from related transportation; b. natural background; c. agricultural management practices and municipal sewage discharge. The study provides information on the effects of spatial variation for the development of the abandoned mining areas and a useful approach to the prioritization of locations for the development and utilization of soil in these areas in China.


Asunto(s)
Metales Pesados , Minería , Contaminantes del Suelo , Niño , China , Ciudades , Monitoreo del Ambiente , Humanos , Manganeso/toxicidad , Metales Pesados/análisis , Medición de Riesgo , Suelo , Contaminantes del Suelo/análisis , Contaminantes del Suelo/toxicidad
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