Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats
Acta cir. bras
; Acta cir. bras;34(3): e201900305, 2019. graf
Article
in En
| LILACS
| ID: biblio-989062
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose:
To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG).Methods:
The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats.Results:
EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue.Conclusion:
This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Stomach Neoplasms
/
Plant Extracts
/
Adenocarcinoma
/
Usnea
/
Acetates
/
Antineoplastic Agents, Phytogenic
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Journal subject:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2019
Document type:
Article
Affiliation country:
Country of publication: