A randomised bouble-blind placebo controlled trial of lidamidine HCL in irritable vowel syndrome
Acta gastroenterol. latinoam
; 30(3): 169-75, jul. 2000. tab, gra
Article
in En
| BINACIS
| ID: bin-11888
Responsible library:
BR1.1
ABSTRACT
BACKGROUND:
We have previously shown electro-mechanical recto-anal alterations in irritable bowel syndrome patients (Awad R. Neurogastroenterol Motil 1993; 5; 265-271). To assess whether the alpha 2-agonist lidamidine HCL is able to modify these physiological alterations and alleviate clinical symptoms, 50 patients with irritable bowel syndrome were studied in a random, double blind, placebo-controlled trial.METHODS:
Lidamidine HCL (4 mg) or placebo was taken orally t.i.d. with food. Fasting and post-prandial electrical and mechanical activities of rectum and internal anal sphincter were recorded before and at the end of treatment. Recto-anal sensitivity was also tested.RESULTS:
After treatment, post-prandial duration of spontaneous recto-anal inhibitory reflex diminished in the lidamidine group (18.9 +/- 1 vs. 15.1 +/- 1.3 sec; p < 0.05). Amplitude of induced rectoanal inhibitory reflex decreased after lidamidine (24.6 +/- 2.9 vs 17.3 +/- 3 mmHg; p = 0.02). Rectal electrical activity showed no changes during basal and post-prandial periods in any group. Rectal painful sensation decreased after treatment with lidamidine (54.8 +/- 5.4 vs 43.6 +/- 3.5 ml; p < 0.05) as well as with placebo (p < 0.05). Abdominal distension and requency, severity and duration of pain diminished in both groups (p < 0.05).CONCLUSION:
Lidamidine decreased the augmented mechanical response to food, reduced rectal sensitivity, and relieved symptoms. These facts suggest that in spite of the strong placebo response obtained, lidamidine HCL can become a useful alternative for treatment of patients with irritable bowel syndrome. (Au)
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Collection:
06-national
/
AR
Database:
BINACIS
Main subject:
Phenylurea Compounds
/
Colonic Diseases, Functional
/
Adrenergic beta-Agonists
/
Gastrointestinal Motility
Type of study:
Clinical_trials
Limits:
Adult
/
Humans
Language:
En
Journal:
Acta gastroenterol. latinoam
Year:
2000
Document type:
Article