Comprehensive lung injury pathology induced by mTOR inhibitors
Clin. transl. oncol. (Print)
; 11(8): 499-510, ago. 2009. tab, ilus
Article
in En
| IBECS
| ID: ibc-123667
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Interstitial lung disease is a rare side effect of temsirolimus treatment in renal cancer patients. Pulmonary fibrosis is characterised by the accumulation of extracellular matrix collagen, fibroblast proliferation and migration, and loss of alveolar gas exchange units. Previous studies of pulmonary fibrosis have mainly focused on the fibroproliferative process in the lungs. However, the molecular mechanism by which sirolimus promotes lung fibrosis remains elusive. Here, we propose an overall cascade hypothesis of interstitial lung diseases that represents a common, partly underlying synergism among them as well as the lung pathogenesis side effects of mammalian target of rapamycin inhibitors (AU)
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Protein Kinases
/
Pulmonary Fibrosis
/
Protein Kinase Inhibitors
/
Lung Injury
/
Lung
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Clin. transl. oncol. (Print)
Year:
2009
Document type:
Article