Molecular study of hypersensitivity to spores in adults and children from Castile & Leon
Allergol. immunopatol
; 47(4): 350-356, jul.-ago. 2019. tab, graf
Article
in En
| IBECS
| ID: ibc-186506
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Introduction and objectives: Biological aerosols play a vital role in the interactions between the atmosphere, biosphere, climate and public health and fungal spores are a component with allergic importance. We constructed a database in Castile & Leon (Spain) and carry out molecular-level component-resolved diagnosis to complete the air quality study carried out since 2006 by our aerobiological network (RACYL) to aid clinical diagnosis and treatment. Methods: We reviewed a database of 19,774 patients (adults and children) with allergic respiratory disease treated in our unit during the last 12 years. We also made a component-resolved diagnosis of the molecules involved in the pathology in a randomly selected population of 150 patients. Results: The dimeric glycoprotein Alt a1 from Alternaria is the most prevalent and most useful allergen in the diagnosis of patients with allergy to fungi in our area (94.4%), followed by enolase Alt a 6 (Alternaria), ribonuclease Asp f 1 of Aspergillus and mannitol dehydrogenase from Cla h 8 (Cladosporium). Conclusions: Our results have helped determine which spore molecules are most-closely associated with allergies. Molecular analysis will be useful to determine more accurate and useful immunotherapy in these patients
RESUMEN
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Aspergillosis
/
Respiratory Hypersensitivity
/
Spores, Fungal
/
Tinea
/
Alternariosis
Limits:
Adult
/
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Allergol. immunopatol
Year:
2019
Document type:
Article