The CXCR5 T follicular helper cell compartment in children with antibody deficienciesin search of a prognostic marker of childhood hypogammaglobulinemia
Allergol. immunopatol
; 49(2): 113-121, mar. 2021. graf, tab
Article
in En
| IBECS
| ID: ibc-214246
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Background Novel immunodiagnostic markers are required in order to discriminate between mild hypogammaglobulinemia and severe humoral primary immune deficiencies in children. The efficacy of an antibody response to infections and vaccines is underpinned by T follicular helper (Tfh) cells, activating an immunoglobulin class switch recombination, somatic hypermutations, and affinity maturation. Objective To determine the formation of the Tfh cells in antibody deficient children and to define their importance as prognostic markers helpful in defining the severity of hypogammaglobulinemia. Methods We retrospectively reviewed medical records of 200 children aged from 2 months to 10 years, in whom hypogammaglobulinemia was assessed, from January to December 2019. In all the children studied, a flow cytometric analysis of the Tfh cell compartment was performed. Results In young infants aged from 2 to 9 months, the mean relative frequency of the Tfh population was lower than in the control population. Concomitantly, the relative values of Tfh cells, corresponding with the 95th percentile, were below the reference values in all age groups. Conclusions A deficiency of Tfh cells in young infants mirrors the immaturity of the humoral immune response, whereas in older children Tfh cells are proposed as a prognostic marker facilitating to distinguish between mild hypogammaglobulinemia and the developing common variable immunodeficiency (AU)
Key words
Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Common Variable Immunodeficiency
/
Th2 Cells
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Agammaglobulinemia
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Receptors, CXCR5
Limits:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Language:
En
Journal:
Allergol. immunopatol
Year:
2021
Document type:
Article