Short- and long-term memory: differential involvement of neurotransmitter systems and signal transduction cascades
An. acad. bras. ciênc
; 72(3): 353-64, Sept. 2000. graf
Article
in En
| LILACS
| ID: lil-269387
Responsible library:
BR1.1
RESUMO
Since William James (1890) first distinguished primary from secondary memory, equivalent to short- and long-term memory, respectively, it has been assumed that short-term memory processes are in charge of cognition while long-term memory is being consolidated. From those days a major question has been whether short-term memory is merely a initial phase of long-term memory, or a separate phenomena. Recent experiments have shown that many treatments with specific molecular actions given into the hippocampus and related brain areas after one-trial avoidance learning can effectively cancel short-term memory without affecting long-term memory formation. This shows that short-term memory and long-term memory involve separate mechanisms and are independently processed. Other treatments, however, influence both memory types similarly, suggesting links between both at the receptor and at the post-receptor level, which should not be surprising as they both deal with nearly the same sensorimotor representations. This review examines recent advances in short- and long-term memory mechanisms based on the effect of intra-hippocampal infusion of drugs acting upon neurotransmitter and signal transduction systems on both memory types.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Signal Transduction
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Central Nervous System
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Neurotransmitter Agents
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Memory
Limits:
Animals
Language:
En
Journal:
An. acad. bras. ciênc
Journal subject:
CIENCIA
Year:
2000
Document type:
Article
Affiliation country:
/
Country of publication: