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Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
Furlanetto, T. W; Nunes Júnior, R. B; Sopelsa, A. M. I; Maciel, R. M. B.
Affiliation
  • Furlanetto, T. W; Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Divisão de Medicina Interna. Porto Alegre. BR
  • Nunes Júnior, R. B; Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Divisão de Medicina Interna. Porto Alegre. BR
  • Sopelsa, A. M. I; Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Divisão de Medicina Interna. Porto Alegre. BR
  • Maciel, R. M. B; Universidade Federal de São Paulo. Departamento de Medicina. Divisão de Endocrinologia. São Paulo. BR
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;34(2): 259-263, Feb. 2001.
Article in En | LILACS | ID: lil-281605
Responsible library: BR1.1
RESUMO
Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 0.370 to 2.085 0.364 pmol I-/æg DNA at 1 ng/ml (P<0.02), to 1.970 0.302 pmol I-/æg DNA at 10 ng/ml (P<0.003), and to 2.038 0.389 pmol I-/æg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 0.408 to 7.312 0.506 pmol I-/æg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Thyroid Gland / Thyrotropin / Estradiol / Iodides Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 2001 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Thyroid Gland / Thyrotropin / Estradiol / Iodides Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 2001 Document type: Article Affiliation country: Country of publication: