Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population
Genet. mol. biol
; 32(2): 264-267, 2009. tab
Article
in En
| LILACS
| ID: lil-513967
Responsible library:
BR1.1
ABSTRACT
Most cases of a predisposition to venous thrombosis are caused by resistance to activated protein C, associated in 95 percent of cases with the Factor V Leiden allele (FVL or R506Q). Several recent studies report a further increased risk of thrombosis by an association between the AB alleles of the ABO blood group and Factor V Leiden. The present study investigated this association with deep vein thrombosis (DVT) in individuals treated at the Hemocentro de Pernambuco in northeastern Brazil. A case-control comparison showed a significant risk of thrombosis in the presence of Factor V Leiden (OR = 10.1), which was approximately doubled when the AB alleles of the ABO blood group were present as well (OR = 22.3). These results confirm that the increased risk of deep vein thrombosis in the combined presence of AB alleles and Factor V Leiden is also applicable to the Brazilian population suggesting that ABO blood group typing should be routinely added to FVL in studies involving thrombosis.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Type of study:
Etiology_studies
/
Risk_factors_studies
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Genet. mol. biol
Journal subject:
GENETICA
Year:
2009
Document type:
Article
Affiliation country: