The beneficial effects of Montelukast against 2 3 7 8 tetrachlorodibenzo dioxin toxicity in female reproductive system in rats
Acta cir. bras
; 31(8): 557-563, Aug. 2016. tab, graf
Article
in En
| LILACS
| ID: lil-792413
Responsible library:
BR1.1
ABSTRACT
ABSTRACT PURPOSE:
To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis.METHODS:
Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed.RESULTS:
The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment.CONCLUSION:
The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Ovary
/
Quinolines
/
Oxidative Stress
/
Polychlorinated Dibenzodioxins
/
Acetates
/
Antioxidants
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2016
Document type:
Article
Affiliation country: