The siderophore 2,3-dihydroxybenzoic acid is not required for virulence of Brucella abortus in BALB/c mice.
Infect Immun
; 67(5): 2615-8, 1999 May.
Article
in En
| MEDLINE
| ID: mdl-10225929
ABSTRACT
2,3-Dihydroxybenzoic acid (DHBA) is the only siderophore described for Brucella, and previous studies suggested that DHBA might contribute to the capacity of these organisms to persist in host macrophages. Employing an isogenic siderophore mutant (DeltaentC) constructed from virulent Brucella abortus 2308, however, we found that production of DHBA is not required for replication in cultured murine macrophages or for the establishment and maintenance of chronic infection in the BALB/c mouse model.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brucella abortus
/
Siderophores
/
Hydroxybenzoates
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Infect Immun
Year:
1999
Document type:
Article
Affiliation country: