[Smooth muscle mesentery associated with Epstein-Barr virus (EBV). Report of a case in a child with a liver transplant under FK506 regimen]. / Tumeur musculaire lisse mésentérique associée au virus d'Epstein-Barr (EBV). A propos d'un cas chez un enfant transplanté hépatique sous FK 506.
Ann Pathol
; 19(1): 46-9, 1999 Mar.
Article
in Fr
| MEDLINE
| ID: mdl-10320913
ABSTRACT
Smooth-muscle tumors, benign and malignant, are increasingly recognized in children who are immunocompromised because of HIV infection and organ transplantation. We report a case of an EBV-associated smooth-muscle tumor, of unusual location arising in a seven-year-old post-transplant patient who was previously treated for a lymphoproliferative disease. Five years after liver transplantation, a mesenteric tumor was diagnosed. The tumor was composed of spindle cells with smooth-muscle features. Immunohistochemical analysis was positive for muscle-specific actin and desmin, negative for EBV latent membrane protein (LMP-1). In situ hybridization revealed nuclear EBV sequences. This case underlines the role of EBV infection in the development of unusual smooth-muscle tumors after organ transplantation. The evolution of these rare tumors is uncertain.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peritoneal Neoplasms
/
Liver Transplantation
/
Smooth Muscle Tumor
/
Herpesvirus 4, Human
/
Mesentery
Type of study:
Risk_factors_studies
Limits:
Child
/
Humans
/
Male
Language:
Fr
Journal:
Ann Pathol
Year:
1999
Document type:
Article