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The insulinotropic mechanism of the novel hypoglycaemic agent JTT-608: direct enhancement of Ca(2+) efficacy and increase of Ca(2+) influx by phosphodiesterase inhibition.
Mukai, E; Ishida, H; Fujimoto, S; Kajikawa, M; Okamoto, Y; Fujita, J; Hamamoto, Y; Tsuura, Y; Yamada, Y; Furukawa, N; Ohta, T; Seino, Y.
Affiliation
  • Mukai E; Department of Metabolism & Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-tu, Kyoto 606-8507, Japan.
Br J Pharmacol ; 129(5): 901-8, 2000 Mar.
Article in En | MEDLINE | ID: mdl-10696088
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Butyrates / Calcium / Calcium Signaling / Cyclohexanes / Hypoglycemic Agents / Insulin Limits: Animals Language: En Journal: Br J Pharmacol Year: 2000 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Butyrates / Calcium / Calcium Signaling / Cyclohexanes / Hypoglycemic Agents / Insulin Limits: Animals Language: En Journal: Br J Pharmacol Year: 2000 Document type: Article Affiliation country: