[Therapeutic strategies in RP (retinitis pigmentosa): light at the end of the tunnel?]. / Therapieversuche bei RP: Licht am Ende des Tunnels?
Klin Monbl Augenheilkd
; 216(2): 83-9, 2000 Feb.
Article
in De
| MEDLINE
| ID: mdl-10730223
ABSTRACT
Retinitis pigmentosa (RP) is a hereditary retinal dystrophy which leads to severe visual impairment or blindness and affects about 3.5/1000 of individuals in the industrial world. During the past decades, numerous animal models carrying mutations analogous to mutations in human RP have been studied to elucidate the molecular mechanisms leading to apoptotic photoreceptor cell death in this disease. Up to date, there is no effective treatment to influence the fatal outcome of RP. Recent progress in basic research promotes the development of new therapeutic strategies. In order to restore visual function in blind individuals, the development of electronic photoreceptor prosthesis is being investigated by several researchgroups. Other promising approaches are somatic gene therapy, the application of growth factors and/or pharmacological agents and the inhibition of photoreceptor cell death by interfering with the apoptotic pathway. However, a better understanding of the molecular events leading to cell loss due to photoreceptor apoptosis will be essential for the development of effective treatment.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retina
/
Genetic Therapy
/
Retinitis Pigmentosa
/
Implants, Experimental
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Country/Region as subject:
Europa
Language:
De
Journal:
Klin Monbl Augenheilkd
Year:
2000
Document type:
Article