Dual effect of IL-4 on resistance to systemic gram-negative infection and production of TNF-alpha.
Cytokine
; 12(4): 417-21, 2000 Apr.
Article
in En
| MEDLINE
| ID: mdl-10805227
ABSTRACT
To determine the effect of interleukin 4 (IL-4) administration in a live sepsis model characterised by high-level production of tumour necrosis factor a (TNF-alpha), mice infected systemically with lethal or sublethal inocula of Pseudomonas aeruginosa were given the recombinant cytokine at different times before infection. Improved survival and decreased TNF-alpha production were observed in lethally infected mice treated with the cytokine 1 day before challenge. In contrast, increased mortality and overproduction of TNF-alpha were observed in sublethally infected mice given IL-4 at the time of infection.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pseudomonas Infections
/
Interleukin-4
/
Tumor Necrosis Factor-alpha
/
Sepsis
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Cytokine
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2000
Document type:
Article
Affiliation country: