Recruitment of chromatin remodeling machines.
J Cell Biochem
; 78(2): 179-85, 2000 May.
Article
in En
| MEDLINE
| ID: mdl-10842313
ABSTRACT
The assembly of eukaryotic DNA into folded nucleosomal arrays has drastic consequences for many nuclear processes that require access to the DNA sequence, including RNA transcription, DNA replication, recombination, and repair. Two types of highly conserved chromatin remodeling enzymes have been implicated as regulators of the repressive nature of chromatin structure ATP-dependent remodeling complexes and nuclear histone acetyltransferases (HATs). Recent studies indicate that both types of enzymes can be recruited to chromosomal loci through either physical interactions with transcriptional activators or via the global accessibility of chromatin during S phase of the cell cycle. Here we review these recent observations and discuss the implications for gene-specific regulation by chromatin remodeling machines.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromatin
/
Saccharomyces cerevisiae Proteins
/
DNA-Binding Proteins
Language:
En
Journal:
J Cell Biochem
Year:
2000
Document type:
Article
Affiliation country: