Age-related effects of TGF-beta on proteoglycan synthesis in equine articular cartilage.
Biochem Biophys Res Commun
; 274(2): 467-71, 2000 Aug 02.
Article
in En
| MEDLINE
| ID: mdl-10913361
ABSTRACT
The synthesis of proteoglycans was measured in normal equine articular cartilage of ages 9 months to 20 years and the effect of TGF-beta1 on this activity was investigated. The rate of incorporation of [(35)S]Na(2)SO(4) decreased with age as did the responsiveness of the tissue to the growth factor. The enhanced synthesis of proteoglycan induced at all ages by TGF-beta1 was down-regulated by IL-1 beta and retinoic acid. The expression of mRNA for TGF-beta1, 2, and 3 was also measured, and although the level of TGF-beta1 was highest at all ages, the expression of each growth factor decreased with age.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteoglycans
/
Aging
/
Cartilage, Articular
/
Transforming Growth Factor beta
/
Horses
Limits:
Animals
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2000
Document type:
Article
Affiliation country: