Tryptophan depletion and risk of depression relapse: a prospective study of tryptophan depletion as a potential predictor of depressive episodes.
Biol Psychiatry
; 48(4): 327-9, 2000 Aug 15.
Article
in En
| MEDLINE
| ID: mdl-10960166
ABSTRACT
BACKGROUND:
This study investigated the relationship between depressive symptom response during tryptophan depletion and future depressive episodes.METHODS:
Twelve subjects with prior major depressive episodes in remission and medication-free for > or =3 months (patients), and 12 matched healthy (control) subjects received two tryptophan depletion tests 1 week apart. During follow-up the Hamilton Depression Rating Scale was administered weekly for 1 month, monthly for 3 months, and once at 6 and 12 months.RESULTS:
With results from both tests, tryptophan depletion has a sensitivity of 78%, specificity of 80%, positive predictive value of 70%, and negative predictive value of 86% to identify future depressive episodes. Survival analysis shows that mood response to tryptophan depletion reliably predicts major depressive episodes during the follow-up year (r =.2725, p =.014).CONCLUSIONS:
Tryptophan depletion may be clinically useful in identifying individuals at risk for future major depressive episodes.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tryptophan
/
Depressive Disorder, Major
Type of study:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Biol Psychiatry
Year:
2000
Document type:
Article
Affiliation country: