The neuroprotective effects of (-)deprenyl in the gerbil hippocampus following transient global ischemia.
J Neural Transm (Vienna)
; 107(7): 779-86, 2000.
Article
in En
| MEDLINE
| ID: mdl-11005543
ABSTRACT
(-)Deprenyl (selegeline) is a monoamine oxidase B (MAO-B) inhibitor, but it also exerts several effects independent of MAO-B inhibition. For example, it has been shown to improve neuronal survival in different neurodegenerative models. In the present study, we have tested whether (-)deprenyl attenuates the neuronal damage in the hippocampus that is induced in a model of transient global ischemia in gerbils. (-)Deprenyl was administered 1) at a low daily dose starting two weeks before occlusion, 2) at a single high dose administered 3h after occlusion, or 3) at a low daily dose for one or two weeks after occlusion. A nonsignificant trend of reduced neuronal damage in the hippocampal CA1 area was seen in all experimental groups treated with (-)deprenyl, regardless of the timing of treatment. The results together with previous evidence suggest that (-)deprenyl may protect CA1 neurons from ischemia-induced delayed death by several possible mechanisms, including the suppression of oxidative stress and apoptotic processes.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Selegiline
/
Brain Ischemia
/
Pyramidal Cells
/
Hippocampus
/
Monoamine Oxidase Inhibitors
Limits:
Animals
Language:
En
Journal:
J Neural Transm (Vienna)
Year:
2000
Document type:
Article
Affiliation country: