Antinociceptive effect of a group II metabotropic glutamate receptor antagonist in the thalamus of monoarthritic rats.
Neurosci Lett
; 296(1): 25-8, 2000 Dec 15.
Article
in En
| MEDLINE
| ID: mdl-11099825
ABSTRACT
Adult rats were rendered monoarthritic (MA) by injection of 50 microl of complete Freund's adjuvant (CFA) into the tibiotarsal joint. The ankle-bend (AB) test of nociception was performed in those animals before and during 60 min after the stereotaxic injection of 2 microl of either saline (controls) or (2S)-alpha-ethylglutamic acid (EGLU, 80 nmol in 2 microl), a group II metabotropic glutamate receptors (mGluR) antagonist, in the reticular thalamic nucleus (Rt) contralateral to the arthritic joint. AB scores reached near maximum values before the stereotaxic injections (18.7+/-0.8), and remained constant throughout the entire experimental period in the control group, denoting marked allodynia. In the EGLU-treated group, AB scores gradually decreased after EGLU injection, with minimum values at 10 min (7.7+/-1.6), recovering to scores near maximum at 60 min (19.7+/-0.3). The data point to an activation of group II mGluR by noxious inputs in the Rt of MA rats, suggesting their participation in inhibiting local gamma-aminobutyric acid (GABA)ergic inhibitory neurones.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain
/
Arthritis, Experimental
/
Thalamic Nuclei
/
Receptors, Metabotropic Glutamate
/
Glutamates
Limits:
Animals
Language:
En
Journal:
Neurosci Lett
Year:
2000
Document type:
Article
Affiliation country: