Second stage of a genome scan of schizophrenia: study of five positive regions in an expanded sample.
Am J Med Genet
; 96(6): 864-9, 2000 Dec 04.
Article
in En
| MEDLINE
| ID: mdl-11121199
ABSTRACT
In a previous genome scan of 43 schizophrenia pedigrees, nonparametric linkage (NPL) scores with empirically derived pointwise P-values less than 0.01 were observed in two regions (chromosomes 2q12-13 and 10q23) and less than 0.05 in three regions (4q22-23, 9q22, and 11q21). Markers with a mean spacing of about 5 cM were typed in these regions in an expanded sample of 71 pedigrees, and NPL analyses carried out. No region produced significant genomewide evidence for linkage. On chromosome 10q, the empirical P-value remained at less than 0.01 for the entire sample (D10S168), evidence in the original 43 pedigrees was slightly increased, and a broad peak of positive results was observed. P-values less than 0.05 were observed on chromosomes 2q (D2S436) and 4q (D4S2623), but not on chromosomes 9q or 11q. It is concluded that this sample is most supportive of linkage on chromosome 10q, with less consistent support on chromosomes 2q and 4q. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96864-869, 2000.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
/
Genome, Human
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Am J Med Genet
Year:
2000
Document type:
Article
Affiliation country: