Calcification and degeneration characteristics of the Biocor no-react bovine internal mammary artery (BIMA) - in vivo evaluation in a sheep model.
Cardiovasc Surg
; 9(1): 44-49, 2001 Feb.
Article
in En
| MEDLINE
| ID: mdl-11137807
ABSTRACT
OBJECTIVE:
The No-React process for biomaterials was suggested to prevent calcification and degeneration. We examined in vivo in a chronic sheep model the performance of a Biocor bovine internal mammary artery (BIMA) graft after No-React processing.METHODS:
'No-React' processing consists of aldehyde cross-linkage following a detoxification process with multiple physical variables and incubation with surfactant. Biocor BIMA No-React treated grafts have been interposed in the carotid artery in seven sheep with a Dacron graft as control. Grafts were explanted after 3 or 6months and were grossly examined, by X-ray, histology, transmission and scanning electron microscopy, and atomic absorption spectrophotometry.RESULTS:
In the BIMA, good healing was found with a smooth intimal surface, minimal inflammatory reaction, and a well preserved ultrastructure. Calcification increased progressively. In the Dacron grafts, a fibrous covering the inner surface and infiltration with fibroblasts, histiocytes and macrophages was noted. Calcium content was stable.CONCLUSION:
Calcification increased progressively in Biocor BIMA No-React grafts. Minimal inflammatory changes, a smooth inner surface and well preserved ultrastructure were noted.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biocompatible Materials
/
Calcinosis
/
Blood Vessel Prosthesis
/
Disease Models, Animal
/
Mammary Arteries
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Cardiovasc Surg
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
Year:
2001
Document type:
Article
Affiliation country: