A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.
Nat Cell Biol
; 2(12): 915-21, 2000 Dec.
Article
in En
| MEDLINE
| ID: mdl-11146656
ABSTRACT
Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-beta signalling pathway). ARTS is expressed in many cells and acts to enhance cell death induced by TGF-beta or, to a lesser extent, by other apoptotic agents. Unlike related septin gene products, ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs. Mutation of the P-loop of ARTS abrogates its competence to activate caspase 3 and to induce apoptosis. Taken together, these observations expand the functional attributes of septins previously described as having roles in cytokinesis and cellular morphogenesis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apoptosis
/
Cytoskeletal Proteins
/
GTP Phosphohydrolases
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Cell Biol
Year:
2000
Document type:
Article
Affiliation country: