[The effects of remifentanil on hemodynamic response to intubation. A comparative study with fentanyl] . / Gli effetti del remifentanil sulla risposta emodinamica all'intubazione. Studio comparativo con il fentanyl.
Minerva Anestesiol
; 66(11): 793-7, 2000 Nov.
Article
in It
| MEDLINE
| ID: mdl-11213546
ABSTRACT
BACKGROUND:
The aim of this study was to evaluate the effects of remifentanil in comparison with those of fentanyl on the hemodynamic response to orotracheal intubation. EXPERIMENTALDESIGN:
prospective comparative and randomized study.SETTING:
operating room in a neurosurgery department at University. PATIENTS 50 patients, ASA I or II with age ranging from 32 to 64 years were divided in two groups randomly.INTERVENTIONS:
25 patients received fentanyl as single bolus dose of 2.0 micrograms/kg and atropine 0.01 mg/kg i.v. as premedication while the remainders received atropine 0.01 mg/kg i.v. and remifentanil 0.2 microgram/kg/min as infusion. All patients were induced with propofol 2.0 mg/kg and cisatracurium 0.15 mg/kg for muscle relaxation and were intubated 4 min after induction of anesthesia. MEASUREMENTS Heart rate, SAP, DAP, MAP and RPP were recorded at different times baseline, induction, intubation, 1, 2, 3 and 4 min after intubation; ECG and pulsoximetry were monitored continuously. Statistical analysis was carried out using ANOVA for repeated measures and Bonferroni t-test a value of p < 0.05 was considered to be significant.RESULTS:
Significant increases in PAS were recorded, at intubation and at 1 min after in patients treated with fentanyl; in the remifentanil group significant decreases in SAP at induction and at 4 min after intubation were recorded. HR increased significantly at intubation and at 1, 2 and 3 min after in the fentanyl group. RPP showed a significant decrease at induction in the remifentanil group and significant increases at intubation and at 1, 2 and 3 min after in patients treated with fentanyl.CONCLUSION:
In conclusion remifentanil was found to properly control the hemodynamic response to intubation in comparison with fentanyl.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Piperidines
/
Fentanyl
/
Anesthetics, Intravenous
/
Intubation, Intratracheal
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
It
Journal:
Minerva Anestesiol
Year:
2000
Document type:
Article