A prospective observational study of 5-, 7-, and 10-day antibiotic treatment for acute otitis media.
Otolaryngol Head Neck Surg
; 124(4): 381-7, 2001 Apr.
Article
in En
| MEDLINE
| ID: mdl-11283494
ABSTRACT
OBJECTIVE:
To compare 5-, 7- and 10-day duration of antibiotic therapy for acute otitis media (AOM) in children. STUDY DESIGN ANDSETTING:
Prospective nonrandomized 1-year evaluation of 3 treatment durations for AOM in a private pediatric setting. Outcomes assessed at 14 +/- 4 days after start of therapy with clinical response categorized as cure, improvement, or failure.RESULTS:
A total of 2172 children were studied; 46.4% were < or =2-years-old. Antibiotics used were amoxicillin (61.9% of patients), trimethoprim/sulfamethoxazole (11.7%), cephalosporins (14.2%), amoxicillin/clavulanate (5.2%), and macrolides/azalides (4.8%). No overall difference in outcome was observed comparing the 5-day (n = 707), 7-day (n = 423), or 10-day (n = 1042) treatments, including children < or =2-years-old. However, in the subset who had an episode of AOM in the preceding month, outcome differed; 5-day treatment was followed by more frequent failure than 10-day treatment (P < 0.001). In logistic regression analysis, variables identified as contributing to a cure were >2-years-old (P < 0.0001), no AOM in the preceding month (P = 0.07), or preceding 12 months (P = 0.03).CONCLUSIONS:
Our study supports the transition from 10 to 5 days for standard AOM antibiotic treatment duration in most patients. A 10-day regimen may be superior in children who have experienced an episode of AOM within the preceding month, a known risk factor for resistant bacterial infection in the otitis-prone patient.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Otitis Media with Effusion
/
Anti-Bacterial Agents
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Otolaryngol Head Neck Surg
Year:
2001
Document type:
Article
Affiliation country: