[Central nervous system tuberculosis in children: 2. Treatment and outcome]. / Tuberculose do sistema nervoso central em crianças: 2. Tratamento e evolução.
Arq Neuropsiquiatr
; 59(1): 77-82, 2001 Mar.
Article
in Fr
| MEDLINE
| ID: mdl-11299436
ABSTRACT
Neurologic damage is usual after central nervous system (CSN) tuberculosis recovery. Treatment is long, difficult and prone to complications. Many factors are enrolled as prognostic determinants. This study aimed to describe the treatment and outcome of 52 children with CNS tuberculosis of a tertiary pediatric hospital. All of them received standard triple drug regimen, and 41 (78.8%) received corticosteroids as adjunctive therapy. Hydrocephalus was common (28 of 41 tested), but only 8 (15.4%) patients underwent ventricular shunt surgery. Hepatotoxicity to anti tuberculosis drugs occurred in 32 (61.5%) cases, but in only 3 (9.4%) drug substitution was necessary. There were 8 (15.4%) deaths and 24 (46.1%) cases developed neurologic damage after therapy. Patients who did not receive steroids during treatment and those with advanced neurological involvement at diagnosis showed a tendency to worse prognosis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adrenal Cortex Hormones
/
Tuberculosis, Central Nervous System
/
Antitubercular Agents
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Fr
Journal:
Arq Neuropsiquiatr
Year:
2001
Document type:
Article
Affiliation country: