In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelic variant forms of human liver microsomal cytochrome P450 2C9: correlation with CYP2C9 genotype and in-vivo pharmacokinetics.

Tang, C; Shou, M; Rushmore, T H; Mei, Q; Sandhu, P; Woolf, E J; Rose, M J; Gelmann, A; Greenberg, H E; De Lepeleire, I; Van Hecken, A; De Schepper, P J; Ebel, D L; Schwartz, J I; Rodrigues, A D

Tang, C; Shou, M; Rushmore, T H; Mei, Q; Sandhu, P; Woolf, E J; Rose, M J; Gelmann, A; Greenberg, H E; De Lepeleire, I; Van Hecken, A; De Schepper, P J; Ebel, D L; Schwartz, J I; Rodrigues, A D.

Affiliation

Tang C; Drug Metabolism, Merck Research Laboratories, West Point, PA, USA. cuyue_tang@merck.com

Pharmacogenetics ; 11(3): 223-35, 2001 Apr.

Article in En | MEDLINE | ID: mdl-11337938

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Collection: 01-internacional Database: MEDLINE Main subject: Steroid Hydroxylases / Sulfonamides / Microsomes, Liver / Aryl Hydrocarbon Hydroxylases / Cyclooxygenase Inhibitors / Cytochrome P-450 Enzyme System / Steroid 16-alpha-Hydroxylase / Alleles / Isoenzymes / Liver Limits: Adult / Humans / Middle aged Language: En Journal: Pharmacogenetics Year: 2001 Document type: Article Affiliation country: Country of publication:

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