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A retro-inverso Prosaptide D5 promotes a myelination process in developing rats.
Hiraiwa, M; Campana, W M; Wang, C Y; Otero, D A; O'Brien, J S.
Affiliation
  • Hiraiwa M; Department of Neurosciences, University of California at San Diego, School of Medicine, Center for Molecular Genetics, La Jolla, CA 92093-0634, USA. mhiraiwa@ucsd.edu
Brain Res Dev Brain Res ; 128(1): 73-6, 2001 May 31.
Article in En | MEDLINE | ID: mdl-11356264
ABSTRACT
The myelinotrophic action of Prosaptide D5 was investigated in developing rats. Sulfatide concentrations in brain and sciatic nerve were determined to assess the development of myelination. Subcutaneous D5-injection significantly increased sulfatide concentrations in both brain and sciatic nerve by 250 and 150% over controls, respectively. D5 promoted ERK phosphorylation in iSC Schwann cells similar to prosaposin. The results showed that D5 treatment stimulated a myelination process in developing rat.
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Collection: 01-internacional Database: MEDLINE Main subject: Aging / Neuroprotective Agents / Myelin Sheath / Nerve Growth Factors Limits: Animals Language: En Journal: Brain Res Dev Brain Res Journal subject: CEREBRO / NEUROLOGIA Year: 2001 Document type: Article Affiliation country:
Search on Google
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Aging / Neuroprotective Agents / Myelin Sheath / Nerve Growth Factors Limits: Animals Language: En Journal: Brain Res Dev Brain Res Journal subject: CEREBRO / NEUROLOGIA Year: 2001 Document type: Article Affiliation country: