Role of mitochondria in amyotrophic lateral sclerosis.
Amyotroph Lateral Scler Other Motor Neuron Disord
; 1(3): 185-90, 2000 Jun.
Article
in En
| MEDLINE
| ID: mdl-11464951
ABSTRACT
Neurodegeneration in amyotrophic lateral sclerosis (ALS) is characterized by the specific loss of central and peripheral motor neurons. While this pattern of neuronal demise gives rise to a distinct clinical syndrome, at the cellular and molecular level ALS pathology is similar to that seen in other neurodegenerative diseases. In particular, mitochondrial dysfunction in ALS is reminiscent of that observed in Alzheimer's and Parkinson's diseases. Mitochondria in persons with ALS demonstrate impaired electron transport, increased free radical generation, and an inability to adequately buffer cytosolic calcium shifts. These abnormalities are probably systemic and potentially due to mutation of mitochondrial DNA.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amyotrophic Lateral Sclerosis
/
Mitochondria
Limits:
Humans
Language:
En
Journal:
Amyotroph Lateral Scler Other Motor Neuron Disord
Journal subject:
NEUROLOGIA
Year:
2000
Document type:
Article
Affiliation country: