Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite.
Proc Natl Acad Sci U S A
; 98(20): 11347-52, 2001 Sep 25.
Article
in En
| MEDLINE
| ID: mdl-11572986
ABSTRACT
The dorsal-ventral polarity of the somite is controlled by antagonistic signals from the dorsal neural tube/surface ectoderm, mediated by WNTs, and from the ventral notochord, mediated by sonic hedgehog (SHH). Each factor can act over a distance greater than a somite diameter in vitro, suggesting they must limit each other's actions within their own patterning domains in vivo. We show here that the growth-arrest specific gene 1 (Gas1), which is expressed in the dorsal somite, is induced by WNTs and encodes a protein that can bind to SHH. Furthermore, ectopic expression of Gas1 in presomitic cells attenuates the response of these cells to SHH in vitro. Taken together, these data suggest that GAS1 functions to reduce the availability of active SHH within the dorsal somite.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trans-Activators
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Proto-Oncogene Proteins
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Somites
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Body Patterning
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Zebrafish Proteins
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Membrane Proteins
Limits:
Animals
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
2001
Document type:
Article
Affiliation country: