Left ventricular remodelling and brain natriuretic peptide after first myocardial infarction.
Heart
; 86(6): 638-42, 2001 Dec.
Article
in En
| MEDLINE
| ID: mdl-11711456
ABSTRACT
OBJECTIVE:
To investigate the relation between brain natriuretic peptide (BNP) concentrations and left ventricular remodelling characteristics after acute myocardial infarction.DESIGN:
Consecutive sample prospective cohort study.SETTING:
District general hospital coronary care unit in the north of England. PATIENTS 133 initial survivors of a first myocardial infarction who received thrombolytic treatment.INTERVENTIONS:
Patients had transthoracic echocardiography and BNP concentrations measured at three to seven days (early) and two months (late). MAIN OUTCOMEMEASURES:
Wall motion index = 1.2, end systolic left ventricular volume index and mortality at one year.RESULTS:
Patients with an early wall motion index of = 1.2 had higher early and late BNP concentrations (early BNP mean (SEM) 629 (76.2) pg/ml v 334 (20.8) pg/ml, p = 0.001 and late BNP 584 (79.5) pg/ml v 343 (25.0) pg/ml, p = 0.001). Patients with an increase in end systolic left ventricular volume index of > 10% also had higher early and late BNP concentrations (early BNP p = 0.034 and late BNP p = 0.001). Early BNP was significantly associated with one year mortality (p = 0.003).CONCLUSIONS:
Higher BNP concentrations early after first myocardial infarction are associated with adverse left ventricular remodelling characteristics. This may help explain why BNP is such a strong predictor of outcome after myocardial infarction.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ventricular Dysfunction, Left
/
Natriuretic Peptide, Brain
/
Ventricular Remodeling
/
Myocardial Infarction
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Heart
Journal subject:
CARDIOLOGIA
Year:
2001
Document type:
Article
Affiliation country: