VLA-2 and VLA-5 cell adhesion molecules expression in CD34+ cells from umbilical cord blood and from bone marrow.
Blood Purif
; 20(2): 174-6, 2002.
Article
in En
| MEDLINE
| ID: mdl-11818681
ABSTRACT
BACKGROUND/AIMS:
Umbilical cord blood contains a large number of early hematopoietic cells with high proliferating capacity, that has been used as an alternative to bone marrow transplantation. The aim of this study is to investigate the number of two cell adhesion molecules in cord blood and in bone marrow.METHODS:
We investigated two integrins, named VLA-2 and VLA-5 (Very Late Appearing Antigen), expressed in the surface of CD34+ cells. The CD34+ cells, isolated with MACS CD34+ isolation kit, were labelled with the appropriate monoclonal antibodies.RESULTS:
Cell adhesion molecules showed highly expressed in both cord blood and bone marrow CD34+ cells.CONCLUSION:
There are no significant differences between the two sources of CD34+ populations.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Marrow Cells
/
Antigens, CD34
/
Integrin alpha2beta1
/
Integrin alpha5beta1
/
Fetal Blood
Limits:
Humans
Language:
En
Journal:
Blood Purif
Year:
2002
Document type:
Article
Affiliation country: