The synthesis and selective IL-2 inhibitory activity of bis piperazine-phenol Mannich adducts.
Bioorg Med Chem Lett
; 12(5): 775-8, 2002 Mar 11.
Article
in En
| MEDLINE
| ID: mdl-11859000
ABSTRACT
Novel phenol bis-Mannich adducts were identified as IL-2 expression inhibitors in a T cell proliferation screening assay. Analogues of the lead compound were prepared through parallel synthesis and a highly selective IL-2 inhibitor was discovered that provided a suitable compound for further optimization.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenols
/
Piperazines
/
Interleukin-2
/
Mannich Bases
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2002
Document type:
Article
Affiliation country: