The sterol-sensing domain: multiple families, a unique role?
Trends Genet
; 18(4): 193-201, 2002 Apr.
Article
in En
| MEDLINE
| ID: mdl-11932020
ABSTRACT
The "sterol-sensing domain" (SSD) is conserved across phyla and is present in several membrane proteins, such as Patched (a Hedgehog receptor) and NPC-1 (the protein defective in Niemann-Pick type C1 disease). The role of the SSD is perhaps best understood from the standpoint of its involvement in cholesterol homeostasis. This article discusses how the SSD appears to function as a regulatory domain involved in linking vesicle trafficking and protein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Structure, Tertiary
/
Membrane Proteins
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Genet
Journal subject:
GENETICA
Year:
2002
Document type:
Article
Affiliation country: