Discovery and evaluation of N-(triazin-1,3,5-yl) phenylalanine derivatives as VLA-4 integrin antagonists.

Porter, John R; Archibald, Sarah C; Brown, Julien A; Childs, Kirstie; Critchley, David; Head, John C; Hutchinson, Brian; Parton, Ted A H; Robinson, Martyn K; Shock, Anthony; Warrellow, Graham J; Zomaya, Alex

Porter, John R; Archibald, Sarah C; Brown, Julien A; Childs, Kirstie; Critchley, David; Head, John C; Hutchinson, Brian; Parton, Ted A H; Robinson, Martyn K; Shock, Anthony; Warrellow, Graham J; Zomaya, Alex.

Affiliation

Porter JR; Celltech R&D Ltd, 216 Bath Road, Slough SL1 4EN, UK. john.porter@celltechgroup.com

Bioorg Med Chem Lett ; 12(12): 1591-4, 2002 Jun 17.

Article in En | MEDLINE | ID: mdl-12039569

ABSTRACT

ABSTRACT

SAR studies aimed at improving the rate of clearance of a series of VLA-4 integrin antagonists by the introduction of a 1,3,5-triazine as an amide isostere are described.

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Collection: 01-internacional Database: MEDLINE Main subject: Phenylalanine / Triazines / Integrin alpha4beta1 Type of study: Evaluation_studies Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2002 Document type: Article Affiliation country:

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