The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man.

Blackie, Josie A; Bloomer, Jackie C; Brown, Murray J B; Cheng, Hung-Yuan; Elliott, Richard L; Hammond, Beverley; Hickey, Deirdre M B; Ife, Robert J; Leach, Colin A; Lewis, V Ann; Macphee, Colin H; Milliner, Kevin J; Moores, Kitty E; Pinto, Ivan L; Smith, Stephen A; Stansfield, Ian G; Stanway, Steven J; Taylor, Maxine A; Theobald, Colin J; Whittaker, Caroline M

Blackie, Josie A; Bloomer, Jackie C; Brown, Murray J B; Cheng, Hung-Yuan; Elliott, Richard L; Hammond, Beverley; Hickey, Deirdre M B; Ife, Robert J; Leach, Colin A; Lewis, V Ann; Macphee, Colin H; Milliner, Kevin J; Moores, Kitty E; Pinto, Ivan L; Smith, Stephen A; Stansfield, Ian G; Stanway, Steven J; Taylor, Maxine A; Theobald, Colin J; Whittaker, Caroline M.

Affiliation

Blackie JA; GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, SG1 2NY, Stevenage, UK.

Bioorg Med Chem Lett ; 12(18): 2603-6, 2002 Sep 16.

Article in En | MEDLINE | ID: mdl-12182870

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Collection: 01-internacional Database: MEDLINE Main subject: Phospholipases A / Pyrimidinones / Biphenyl Compounds / Enzyme Inhibitors / Lipoproteins Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2002 Document type: Article Affiliation country:

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