Follow up of fetal outcome in cases of maternal phenylketonuria in Northern Ireland.
Arch Dis Child Fetal Neonatal Ed
; 87(2): F141-3, 2002 Sep.
Article
in En
| MEDLINE
| ID: mdl-12193524
ABSTRACT
BACKGROUND:
Maternal phenylketonuria (PKU) can result in multiple congenital anomalies. In Northern Ireland, the prevalence of PKU is relatively high at 1 in 4000.OBJECTIVE:
To assess the outcome of 39 pregnancies in 20 mothers.RESULTS:
Dietary control was established before conception in 17 pregnancies (44%). Five mothers with hyperphenylalaninaemia had 11 pregnancies. There were no congenital anomalies in this group, and all appear to be developing normally. Fifteen women with classical PKU had 28 pregnancies. One pregnancy ended in a first trimester miscarriage. Twelve out of 27 (44%) completed pregnancies produced babies with a congenital anomaly and/or developmental delay.CONCLUSIONS:
Most problems occurred when dietary control was not established until after the 2nd trimester. As the cohort of young women with treated PKU is growing steadily, maternal PKU is going to become an even greater cause for concern.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenylketonurias
/
Pregnancy Complications
/
Congenital Abnormalities
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Child
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Europa
Language:
En
Journal:
Arch Dis Child Fetal Neonatal Ed
Journal subject:
PEDIATRIA
/
PERINATOLOGIA
Year:
2002
Document type:
Article
Affiliation country: