Extracellular putrescine content after acute excitotoxic brain damage in the rat.
Neurosci Lett
; 330(1): 74-8, 2002 Sep 13.
Article
in En
| MEDLINE
| ID: mdl-12213638
ABSTRACT
We examined the effects of the local infusion of kainic acid (KA), by reverse dialysis in the rat striatum, on the concentration of polyamines in the extracellular striatal compartment and in tissue. KA infusion markedly increased (3-fold) extracellular putrescine (PUT) concentration, which reached its maximum at the end of the dialysis experiments (6 h). Tissue PUT concentration was also increased (2-fold) in the striatum perfused with KA but not in the contralateral side. Extracellular spermidine (SD) concentration but not tissue SD concentration was affected by KA. The increase in PUT was accompanied by histological damage around the probe and by an increase in ornithine decarboxylase content, as assessed by immunohistochemistry. These results indicate that in the first stages of the excitotoxic lesion, there is an increase in the extracellular concentrations of PUT and SD.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Putrescine
/
Hypoxia, Brain
/
Excitatory Amino Acid Agonists
/
Extracellular Space
Limits:
Animals
Language:
En
Journal:
Neurosci Lett
Year:
2002
Document type:
Article
Affiliation country: