Peripheral inflammatory response in Alzheimer's disease and multiinfarct dementia.
Neurobiol Dis
; 11(2): 308-14, 2002 Nov.
Article
in En
| MEDLINE
| ID: mdl-12505423
ABSTRACT
Whether peripheral inflammatory molecules can be considered markers of dementia is still an open issue. We have investigated the presence of circulating cytokines and the ability of blood cells to release them in response to an inflammatory stimulus in patients with different types of dementia and in age-matched controls. A significant increase in circulating interleukin-1beta in moderate Alzheimer and in multiinfarct (145 and 224 times control concentration, respectively) dementia and in circulating tumor necrosis factor-alpha concentration in multiinfarct dementia patient group (156%) were found. Tumor necrosis factor-alpha and interleukin-6 released from blood cells after exposure to lipopolysaccharide were significantly reduced in moderate Alzheimer (60%, both cytokines) and multiinfarct patients (71 and 50%, respectively), while interleukin-10 was decreased only in multiinfarct patients (61%). The results show that patients with Alzheimer disease or multiinfarct dementia have an upregulation of circulating cytokines and a downregulation of cytokines released by blood cells.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dementia, Multi-Infarct
/
Down-Regulation
/
Up-Regulation
/
Cytokines
/
Encephalitis
/
Alzheimer Disease
/
Leukocytes
Limits:
Humans
Language:
En
Journal:
Neurobiol Dis
Journal subject:
NEUROLOGIA
Year:
2002
Document type:
Article
Affiliation country: