[Structures and pharmacological activities of beesiosides O and P].
Yao Xue Xue Bao
; 37(10): 788-92, 2002 Oct.
Article
in Zh
| MEDLINE
| ID: mdl-12567863
ABSTRACT
AIM:
To investigate the chemical constituents of the rhizomes of Beesia calthaefolia native to China in order to obtain a more comprehensive understanding of its effective components.METHODS:
Compounds were isolated by column chromatography with silica gel. Their structures were elucidated by spectral analysis and chemical evidence. Compounds identified were subjected to pharmacological evaluation.RESULTS:
Two novel compounds were isolated and identified as (20S, 24S)-15 alpha-acetoxy-16 beta, 24; 20, 24-diepoxy-9, 19-cyclolanostane-3 beta, 25-diol-3-O-beta-D-xylopyranoside (I) and (20S, 24R)-15 alpha-acetoxy-9, 19-cyclolanostane-3 beta, 16 beta, 20, 24, 25-pentaol-3-O-beta-D-xylopyranoside (II), named beesioside O and beesioside P.CONCLUSION:
Compounds I and II are new compounds. Compounds I exhibited immunosuppressive activity and could inhibit angiogenesis as well as inhibit the proliferation of osteoblast. Compound II displayed remarkable inhibition activity against calcium channel receptor.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plants, Medicinal
/
Saponins
/
Ranunculaceae
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Zh
Journal:
Yao Xue Xue Bao
Year:
2002
Document type:
Article
Affiliation country: