A pre-seasonal birch/hazel sublingual immunotherapy can improve the outcome of grass pollen injective treatment in bisensitized individuals. A case-referent, two-year controlled study.
Allergol Immunopathol (Madr)
; 31(1): 31-43, 2003.
Article
in En
| MEDLINE
| ID: mdl-12573207
ABSTRACT
BACKGROUND:
The study tests the hypothesis of a reduction of priming due to tree allergy in patients sensitised to both birch/hazel and grass pollen undergoing an associated preseasonal Sublingual/Injective immunotherapy.METHODS:
36 out of 49 bisensitized candidates were pair-matched into 18 case-referent couples. During two years all patients were administered preseasonal grass-SIT and one patient in each couple received also birch/hazel-SLIT. Diary cards were fulfilled for three consecutive grass pollen seasons. Specific Nasal Provocation Test (NPT) for grass and aspecific bronchial challenge were done; sera were analyzed for specific IgE and IgG.RESULTS:
During the peak of the grass pollen season both groups showed a significant improvement in total symptom-score. Conjunctivitis and cough improved significantly more in patients with associated therapies. While antihistamine score decreased significantly in both groups, antiasthmatics did only in the SLIT-SIT group. The follow-up documented a significant increase in grass- and birch-specific IgG and a decrease in grass-specific IgE. Grass-NPT threshold was clearly higher in SLIT-SIT-group (p = 0.01) and only in this group PD20 methacholine improved significantly (p < 0.05).CONCLUSIONS:
Combined birch/hazel-SLIT and grass-SIT are safe and improve clinical outcomes of SIT alone in young bisensitized patients. Priming reduction is supported by specific NPT and bronchial hyperresponsiveness.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pollen
/
Asthma
/
Allergens
/
Rhinitis, Allergic, Seasonal
/
Desensitization, Immunologic
/
Betula
/
Corylus
/
Poaceae
Type of study:
Clinical_trials
/
Etiology_studies
Country/Region as subject:
Europa
Language:
En
Journal:
Allergol Immunopathol (Madr)
Year:
2003
Document type:
Article
Affiliation country: