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Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin alphavbeta3) antagonists.
Miller, William H; Manley, Peter J; Cousins, Russell D; Erhard, Karl F; Heerding, Dirk A; Kwon, Chet; Ross, Stephen T; Samanen, James M; Takata, Dennis T; Uzinskas, Irene N; Yuan, Catherine C K; Haltiwanger, R Curtis; Gress, Catherine J; Lark, Michael W; Hwang, Shing Mei; James, Ian E; Rieman, David J; Willette, Robert N; Yue, Tian Li; Azzarano, Leonard M; Salyers, Kevin L; Smith, Brian R; Ward, Keith W; Johanson, Kyung O; Huffman, William F.
Affiliation
  • Miller WH; GlaxoSmithKline Pharmaceuticals, 1250 S. Collegeville Rd., PO Box 5089, PA 19426, USA. william_h_miller@gsk.com
Bioorg Med Chem Lett ; 13(8): 1483-6, 2003 Apr 17.
Article in En | MEDLINE | ID: mdl-12668017
ABSTRACT
In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified by 16, which have good potency and excellent oral bioavailability (approximately 100% in rats). This new series is derived conceptually from opening of the seven-membered ring of SB-265123.
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Collection: 01-internacional Database: MEDLINE Main subject: Phenylbutyrates / Integrin alphaVbeta3 Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2003 Document type: Article Affiliation country:
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Phenylbutyrates / Integrin alphaVbeta3 Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2003 Document type: Article Affiliation country: