Induction of micronucleated erythrocytes in mouse peripheral blood after cutaneous application of 5-fluorouracil.
Arch Med Res
; 34(2): 141-4, 2003.
Article
in En
| MEDLINE
| ID: mdl-12700011
ABSTRACT
BACKGROUND:
For topically applied drugs such as 5-fluorouracil (5-FU), dosage is not as precise as for other drug administration pathways. Consequently, quantity of drug delivered may differ among individuals and applications. 5-FU is used in treatment of different diseases and has been reported as a clastogenic compound by micronucleus assay.METHODS:
To determine whether 5-FU cream (5% 5-FU) absorbed through skin can produce genotoxic or cytotoxic effect in mouse bone marrow, induction of micronucleated erythrocytes (MNE) in mouse peripheral blood was examined after cutaneous application of 5-FU daily for 5 days.RESULTS:
5-FU cream induced significant micronuclei at doses of 37.5 mg (total weight of cream)/2 cm(2) and 75.0 mg/2 cm(2), as well as cytotoxic effects at doses of 150.0 and 300.0 mg/2 cm(2).CONCLUSIONS:
Cutaneous application of 5-FU increased number of MNE in mouse peripheral blood. These data emphasize the importance of using correct dose when applying drugs topically.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Micronuclei, Chromosome-Defective
/
Erythrocytes
/
Fluorouracil
Limits:
Animals
Language:
En
Journal:
Arch Med Res
Journal subject:
MEDICINA
Year:
2003
Document type:
Article
Affiliation country: