Your browser doesn't support javascript.
loading
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections.
Choudhry, Anthony E; Mandichak, Tracy L; Broskey, John P; Egolf, Richard W; Kinsland, Cynthia; Begley, Tadhg P; Seefeld, Mark A; Ku, Thomas W; Brown, James R; Zalacain, Magdalena; Ratnam, Kapila.
Affiliation
  • Choudhry AE; Microbial, Musculoskeletal and Proliferative Diseases and Bioinformatics, GlaxoSmithKline Pharmaceuticals, Collegeville Pennsylvania 19426, USA.
Antimicrob Agents Chemother ; 47(6): 2051-5, 2003 Jun.
Article in En | MEDLINE | ID: mdl-12760898
ABSTRACT
Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Staphylococcus aureus / Phosphotransferases (Alcohol Group Acceptor) / Enzyme Inhibitors Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2003 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Staphylococcus aureus / Phosphotransferases (Alcohol Group Acceptor) / Enzyme Inhibitors Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2003 Document type: Article Affiliation country: