Single-cell irradiation from [211At] astatine-labeled C215 monoclonal antibody: improved estimates of radiosensitivity from measurements on cellular uptake and retention.
Anticancer Res
; 23(2B): 1219-21, 2003.
Article
in En
| MEDLINE
| ID: mdl-12820374
ABSTRACT
New data on the biological effect of 211At-C215 monoclonal antibody in a slowly rotating, widely dispersed single-cell suspension of the human cancer cell line Colo-205 is presented. Cell growth curves of each experiment were used to calculate an apparent cell survival after irradiation. Uptake measurements provided the data needed to calculate the average number of 211At decays per cell in the cell suspension. The results from each experiment were then fit to a mono-exponential function. From the exponential fit, an average of 35 +/- 2 (SD) astatine-211 decays per cell are required for 37% apparent cell survival (D0).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenocarcinoma
/
Astatine
/
Colonic Neoplasms
/
Alpha Particles
/
Antibodies, Monoclonal
Limits:
Humans
Language:
En
Journal:
Anticancer Res
Year:
2003
Document type:
Article
Affiliation country: