Drug-induced stabilisation of a mismatched C-T base pair in a DNA hairpin.
Chem Commun (Camb)
; (15): 1814-5, 2003 Aug 07.
Article
in En
| MEDLINE
| ID: mdl-12931980
ABSTRACT
We have shown that a key feature of drug binding, namely specific G-C base pair recognition at a 5'-TG step, can induce a number of novel structural features when an extrahelical base is inserted in close proximity to the drug binding site; we have clearly demonstrated the formation of a stabilised C-T mismatched base pair at a non-terminal site.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA
/
Nogalamycin
/
Base Pair Mismatch
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2003
Document type:
Article