Disease-driven T cell activation predicts immune responses to vaccination against melanoma.
Cancer Immun
; 3: 12, 2003 Sep 09.
Article
in En
| MEDLINE
| ID: mdl-12962476
ABSTRACT
Tumor vaccines may induce activation and expansion of specific CD8 T cells which can subsequently destroy tumor cells in cancer patients. This phenomenon can be observed in approximately 5-20% of vaccinated melanoma patients. We searched for factors associated with T cell responsiveness to peptide vaccines. Peptide antigen-specific T cells were quantified and characterized ex vivo before and after vaccination. T cell responses occurred primarily in patients with T cells that were already pre-activated before vaccination. Thus, peptide vaccines can efficiently boost CD8 T cells that are pre-activated by endogenous tumor antigen. Our results identify a new state of T cell responsiveness and help to explain and predict tumor vaccine efficacy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphocyte Activation
/
T-Lymphocyte Subsets
/
CD8-Positive T-Lymphocytes
/
Cancer Vaccines
/
Melanoma
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Cancer Immun
Journal subject:
ALERGIA E IMUNOLOGIA
/
NEOPLASIAS
Year:
2003
Document type:
Article
Affiliation country: