Digital fluoroscopy to quantify lung tumor motion: potential for patient-specific planning target volumes.
Int J Radiat Oncol Biol Phys
; 57(3): 717-23, 2003 Nov 01.
Article
in En
| MEDLINE
| ID: mdl-14529776
ABSTRACT
PURPOSE:
To apply digital fluoroscopy integrated with CT simulation to measure lung tumor motion and aid in the quantification of individualized planning target volumes. METHODS AND MATERIALS A flat panel digital fluoroscopy unit was modified and integrated with a CT simulator. The stored fluoroscopy images were overlaid with digitally reconstructed radiographs, allowing measurement of the observed lung tumor motion in relation to the corresponding contours on the static digitally reconstructed radiographs. CT simulation and digital fluoroscopy was performed on 10 patients with non-small-cell lung cancer. Actual tumor motion was measured in three dimensions using the overlaid images.RESULTS:
Combining the dynamic data with digitally reconstructed radiographs allowed the tumor shadow from the fluoroscopy to be tracked in relation to the CT lung tumor contour. For all patients, the extent of tumor motion in three dimensions was unique. The motion was greatest in the superoinferior direction and minimal in the AP and lateral directions.CONCLUSION:
We have developed a tool that allows CT simulation to be combined with digital fluoroscopy. Quantitative evaluation of the tumor motion in relation to the CT plan allows for customization of the planning target volume. The variability observed clearly demonstrates the need to generate patient-specific internal motion margins.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Computer Simulation
/
Radiotherapy Planning, Computer-Assisted
/
Fluoroscopy
/
Carcinoma, Non-Small-Cell Lung
/
Lung Neoplasms
/
Movement
Limits:
Adult
/
Aged
/
Aged80
/
Humans
/
Middle aged
Language:
En
Journal:
Int J Radiat Oncol Biol Phys
Year:
2003
Document type:
Article
Affiliation country: