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Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction.
Pera, Edgar M; Ikeda, Atsushi; Eivers, Edward; De Robertis, Eddy M.
Affiliation
  • Pera EM; Howard Hughes Medical Institute and Department of Biological Chemistry, University of California-Los Angeles, Los Angeles, CA 90095-1662, USA.
Genes Dev ; 17(24): 3023-8, 2003 Dec 15.
Article in En | MEDLINE | ID: mdl-14701872
How do very diverse signaling pathways induce neural differentiation in Xenopus? Anti-BMP (Chordin), FGF8, and IGF2 signals are integrated in the embryo via the regulation of Smad1 phosphorylation. Neural induction results from the combined inhibition of BMP receptor serine/threonine kinases and activation of receptor tyrosine kinases that signal through MAPK and phosphorylate Smad1 in the linker region, further inhibiting Smad1 transcriptional activity. This hard-wired molecular mechanism at the level of the Smad1 transcription factor may help explain the opposing activities of IGF, FGF, and BMP signals not only in neural induction, but also in other aspects of vertebrate development.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Trans-Activators / Bone Morphogenetic Proteins / Mitogen-Activated Protein Kinases / DNA-Binding Proteins / Embryonic Induction / Nervous System Limits: Animals Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2003 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Trans-Activators / Bone Morphogenetic Proteins / Mitogen-Activated Protein Kinases / DNA-Binding Proteins / Embryonic Induction / Nervous System Limits: Animals Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2003 Document type: Article Affiliation country: Country of publication: